The invention discloses a 2-bit dicarbonyl substituted pyrrole compound and a preparation method thereof, and belongs to the technical field of synthesis of pyrrole derivatives. The technical scheme is that the general structural formula of the 2-bit dicarbonyl substituted pyrrole compound is as shown in the specification. According to the preparation method, 2-bit double-carbonylation of pyrrole is achieved by the aid of one-step cascade reaction, a series of multifunctional 2-bit dicarbonyl substituted pyrrole compounds are synthesized, and the preparation method lays a foundation for further derivatization research of the compound and synthesized pharmaceutical molecules containing pyrrole structures.

2-bit dicarbonyl substituted pyrrole compound and preparation method thereof

The invention discloses a compound capable of improving the lethality of NK cells on stomach cancer and a preparation method of the compound. The compound is a pyrrole compound with a special general formula. The invention further provides a medicine preparation containing the pyrrole compound and containing a pharmaceutically acceptable carrier, and the pharmaceutically acceptable preparation is prepared. In the cellular level, the pyrrole compound can effectively enhance the killing activity of the NK cells on stomach cancer cells, and has certain concentration dependence. In the animal level, the provided pyrrole compound has a remarkable in-vivo inhibition function on nude mouse stomach cancer transplantation tumor, and according to the cellular level experiment result, it is possible that the pyrrole compound achieves the in-vivo tumor inhibition effect by improving the killing function of the NK cells on stomach cancer transplantation tumor. The provided pyrrole compound and the preparation thereof can be used for preparing medicines capable of improving the lethality of the NK cells on stomach cancer.

Compound capable of improving lethality of NK cells on stomach cancer and preparation method of compound

The invention discloses a compound for improving the gastric cancer killability of CIK cells, and a preparation thereof The compound is a pyrrole compound having a specific general structure The pharmaceutical preparation also provided by the invention contains the pyrrole compound and further contains a pharmaceutically acceptable carrier, and the preparation is processed to prepare a pharmaceutically acceptable dosage form The pyrrole compound provided by the invention can effectively enhance the gastric cancer cell killability of the CIK cells at the cellular level, and has certain concentration dependence; and the pyrrole compound has a significant in-vivo inhibition effect on nude mouse gastric cancer transplantation tumors at the animal level, and a result of animal level experiments is combined with a result of cell level experiments to show that the pyrrole compound is likely to improve the killing effect of the CIK cells on gastric cancer tumors in order to realize the in-vivo tumor inhibition effect The pyrrole compound and the preparation thereof can be used to prepare medicines for improving the gastric cancer killability of the CIK cells

Compound for improving gastric cancer killability of CIK cells, and preparation thereof

The invention discloses a 3-dicarbonyl substitution indole compound and a preparation method thereof, and belongs to the technical field of synthesis of indole derivatives. According to the technical scheme, the 3-dicarbonyl substitution indole compound is characterized by being of the structural formula specified in the description. The invention further discloses the preparation method of the 3-dicarbonyl substitution indole compound. Indole 3 double carbonylation is achieved through a one-step cascade reaction, a series of multi-functionalization 3-dicarbonyl substitution indole compounds are synthetized, and a foundation is laid for further derivation research and synthesis of medicine molecules containing an indole structure.

3-dicarbonyl substitution indole compound and preparation method thereof

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2-bit dicarbonyl substituted pyrrole compound and preparation method thereof

3-dicarbonyl substitution indole compound and preparation method thereof