The disclosure relates to respiratory virus ribonucleic acid (RNA) vaccines and combination vaccines, as well as methods of using the vaccines and compositions comprising the vaccines.

Combination PIV3/hMPV RNA vaccines

The present application generally relates to the development of live attenuated Pneumoviridae strains suitable for use as a vaccine Particularly, human metapneumovirus (hMPV) ΔM2-2 strains (rhMPV-E30M31 and rhMPV-E40L42D44) containing point mutations in a PDZ motif of M2-2, which results in a strain that is both attenuated and immunogenic and, notably, maintains the function of F and G proteins These live attenuated hMPV strains should be suitable for use in a vaccine capable of providing protection against respiratory infection elicited by hMPV Additionally, human respiratory syncytial virus (hRSV) strains containing point mutations in a PDZ motif of M2-2 should also be suitable for use as a vaccine capable of providing protection against respiratory infection elicited by hRSV These Pneumoviridae strains should be useful in vaccines for use in humans and animals, eg, companion animals and livestock, in treating or providing immunoprotection against respiratory infections

Live attenuated recombinant hmpv with mutations in pdz motifs of m2-2 protein, vaccine containing and use thereof

hMPV RNA vaccines

HPIV3 RNA vaccines

Betacoronavirus mRNA vaccine

The present invention provides compositions useful to induce immune response to human metapneumovirus. Also provided are related materials and methods, including methods to induce an immune response in a mammal, comprising administering the compositions herein. In a particular embodiment described herein is a composition comprising a nucleic acid molecule encoding a human metapneumovirus (hMPV) having a mutated integrin-binding motif (RGD motif) in a fusion (F) protein of hMPV, wherein the RGD motif is mutated as compared to wildtype hMPV.

Metapneumovirus immunogens and related materials and methods

Described herein are mutant pneumoviruses comprising a nucleotide sequence which encodes a mutated zinc binding motif in an M2-1 protein of the pneumovirus, wherein the zinc binding motif is mutated relative to wild-type pneumovirus. The mutant pneumoviruses described herein grow to high titer in cell culture, are genetically stable, are attenuated in vitro and in vivo, and are highly immunogenic. Also described herein are vaccines and vaccine compositions comprising the live attenuated mutant pneumoviruses. Vaccine compositions can further comprise a pharmaceutically acceptable carrier, vehicle, excipient, and/or adjuvant. Methods for inducing a protective immune response in a subject against a pneumovirus infection are also described and disclosed. The vaccine compositions and methods described herein can be used to prevent metapneumovirus and respiratory syncytial virus infection in humans, respiratory syncytial virus infection in cattle, avian metapneumovirus infection in various avian species, and pneumonia virus of mice in rodents.

Live attenuated vaccines for pneumoviruses and related methods and materials

The current disclosure relates to methods, compositions and kits for detecting modified adenosine in a target RNA molecule. Aspects relate to a method for detecting modified adenosine in a target ribonucleic acid (RNA) comprising contacting the target RNA with an adenosine deaminase enzyme (adenosine deaminase, RNA-specific) to generate a target RNA with deaminated adenosines and sequencing the target RNA with deaminated adenosines; wherein the modified adenosine is detected when the nucleotide sequence includes adenosine within a m6A motif.

Methods and compositions for treating negative-sense single-stranded rna virus

Disclosed herein are vaccines, immunogenic compositions, and methods of using the same to treat and prevent respiratory syncytial virus (RSV). Specifically, disclosed are immunogenic compositions wherein a protein or immunogenic fragment of RSV is delivered to a subject in a recombinant viral vector platform, such as vesicular stomatis virus (rVSV).

Vaccines and methods of making and using vaccines for prevention of respiratory syncytial virus (rsv) infections

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Papers

Metapneumovirus immunogens and related materials and methods

Live attenuated vaccines for pneumoviruses and related methods and materials

Methods and compositions for treating negative-sense single-stranded rna virus

Vaccines and methods of making and using vaccines for prevention of respiratory syncytial virus (rsv) infections