Bipolar endoscopic enucleation of the prostate (BEEP) was recommended by the 2016 EAU guidelines as the first choice of surgical treatment in men with a substantially enlarged prostate and moderate-to-severe lower urinary tract symptoms. The main aim of this study was to compare a modified diode laser enucleation of the prostate (DiLEP) to BEEP. A total of 114 patients with prostate (20–160 mL) were randomized 1:1 into either DiLEP or BEEP in a dual-centre, non-inferiority-design randomized-controlled trial. The primary outcomes included Qmax and IPSS at 12 months. Non-inferiority was evaluated by comparing the two-sided 95% CI for the mean differences of Qmax and IPSS. Secondary endpoints included other perioperative parameters, postoperative micturition variables, and complication rate. A total of 111 patients (97%) had completed the intent-to-treat analysis, The results showed that DiLEP was comparable to BEEP regarding Qmax (28.0 ± 7.0 vs. 28.1 ± 7.2 mL/s) and IPSS (3.0 ± 2.2 vs. 2.9 ± 2.6) at 12 months, the non-inferiority was met for both Qmax and IPSS. There were also no significant difference between two groups regarding tissue removal rate (71.8 vs. 73.8%), hemoglobin decrease (0.33 ± 0.66 vs. 0.36 ± 0.75 g/dL), sodium decrease (1.0 ± 2.7 vs. 0.3 ± 2.9 mmol/L), and Clavien III complications (5.3 vs. 1.8%) at 12 months. This DiLEP is an anatomical endoscopic enucleation technique for the treatment of benign prostatic hyperplasia, it is non-inferior to BEEP regarding Qmax and IPSS at 12 months postoperatively.

Dual-centre randomized-controlled trial comparing transurethral endoscopic enucleation of the prostate using diode laser vs. bipolar plasmakinetic for the treatment of LUTS secondary of benign prostate obstruction: 1-year follow-up results

目的 评价腔内剜除法在经尿道前列腺汽化电切除术(TUVP)中的应用价值.方法在前列腺双极汽化电切术中结合镜鞘及电切袢的应用,于前列腺尖部寻找到增生腺体和外科包膜的界面,沿此间隙将增生腺体从外科包膜上环状剥离、剜除,切碎.通过临床1000例应用研究,对术中出血量、手术时间、安全性及术后出血时间、出血量及拔除尿管时间和预后效果进行观察分析.结果采用新的切割方法前列腺尖部被完整剜除,无需修整,尖部尿道成为由外科包膜构成的喇叭口状自然界面,经过剜除的增生腺体,界面清楚,血供减少,利于快速切除,不易出现包膜损伤,切除效率明显提高.1000例手术顺利,术后发生短期尿道刺激症者150例,发生膀胱颈挛缩6例,尿道狭窄10例.手术时间、出血量随着前列腺体积和重量的增加而相应延长或增加,与前列腺体积、重量呈正相关(P＜0.05).随访6～18个月,无死亡病例,无再次手术及永久性尿失禁等并发症发生.结论腔内剜除术是TUVP术中一种切实可行的新技术,值得临床应用与推广。

Intraluminalenucleation in transurethral vaporization and electro-resection of the prostate

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Intraluminalenucleation in transurethral vaporization and electro-resection of the prostate