8 Papers
215 Citations
Li Guan is an academic researcher from Science Applications International Corporation. The author has contributed to research in topics: Nasopharyngeal carcinoma & Population. The author has an hindex of 7, co-authored 8 publications. Previous affiliations of Li Guan include Saint Petersburg State University & National Institutes of Health.
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Papers
Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China
Xiuchan Guo,Cheryl A. Winkler,Ji Li,Li Guan,Minzhong Tang,Jian Liao,Hong Deng,Yi Zeng,Stephen J. O'Brien +8 more
TL;DR: It is shown for the first time that these factors influence NPC development independent of environmental risk factors and that the SNP alone cannot serve as a predictive/diagnostic marker for NPC.
A population-based study to investigate host genetic factors associated with hepatitis B infection and pathogenesis in the Chinese population
TL;DR: The identification of allelic polymorphisms in genes involved in the pathway leading to chronic viral infection, liver cirrhosis and, ultimately, hepatocellular carcinoma would provide insights to those factors leading to HBV replication, liver inflammation, fibrosis, and the carcinogenic process.
The Principal Genetic Determinants for Nasopharyngeal Carcinoma in China Involve the HLA Class I Antigen Recognition Groove
Minzhong Tang,James A. Lautenberger,Xiaojiang Gao,Xiaojiang Gao,Efe Sezgin,Sher L. Hendrickson,Jennifer L. Troyer,Victor A. David,Li Guan,Carl E. Mcintosh,Xiuchan Guo,Xiuchan Guo,Yuming Zheng,Jian Liao,Hong Deng,Michael Malasky,Bailey Kessing,Cheryl A. Winkler,Mary Carrington,Yi Zeng,Yi Zeng,Stephen J. O'Brien +21 more
TL;DR: Nasopharyngeal carcinoma resistance alleles carrying the strongly associated amino acid variants implicate specific class I peptide recognition motifs in HLA-A and -B peptide binding groove as conferring strong genetic influence on the development of NPC in China.
A Common HLA–DPA1 Variant is a Major Determinant of Hepatitis B Virus Clearance in Han Chinese
TL;DR: HLA - DPA1 rs3077 T was strongly associated with decreased risk of chronic HBV infection and it was showed for the first time to the knowledge that it is a predictor for HBV clearance, however,rs3077 was not associated with the development of cirrhosis or hepatocellular carcinoma.
Haplotype-dependent HLA susceptibility to nasopharyngeal carcinoma in a Southern Chinese population.
Minzhong Tang,Yi Zeng,A. Poisson,Darlene Marti,Li Guan,Yuming Zheng,Hong Deng,Jian Liao,Xiuchan Guo,Xiuchan Guo,Shouheng Sun,George W. Nelson,Cheryl A. Winkler,Stephen J. O'Brien,Mary Carrington,Xiaojiang Gao +15 more
TL;DR: Stratified analysis performed in this study clearly demonstrated that while NPC protection is associated with independent HLA alleles, most NPC susceptibility is strictly associated with HLA haplotypes.
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