20 Papers
59 Citations
Li Fu is an academic researcher from Tianjin Medical University. The author has contributed to research in topics: Insulin resistance & Biology. The author has an hindex of 13, co-authored 20 publications.
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Papers
mTOR and autophagy in normal brain aging and caloric restriction ameliorating age-related cognition deficits.
TL;DR: A decline of autophagic degradation in mice hippocampus is shown in correlation with age-dependent cognitive dysfunction, whereas the activity of mTOR and its upstream brain-derived neurotrophic factor)/phosphatidylinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling was decreased with aging.
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AMPK binds to Sestrins and mediates the effect of exercise to increase insulin-sensitivity through autophagy.
TL;DR: It is believed that exercise-induced AMPK and Sestrins interaction may be involved in the beneficial metabolic effects of exercise by activating autophagy, which provides a molecular mechanism that is a potential target in metabolic syndromes.
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Demyelination Determinants Map to the Spike Glycoprotein Gene of Coronavirus Mouse Hepatitis Virus
TL;DR: Deyelination is the pathologic hallmark of the human immune-mediated neurologic disease multiple sclerosis, and viral persistence is insufficient to induce demyelination, although it may be a prerequisite for the development of demYelination.
Sestrin 2 induces autophagy and attenuates insulin resistance by regulating AMPK signaling in C2C12 myotubes.
TL;DR: Investigation of the effects of Sesn2 on the components of the insulin signaling pathway and insulin‐stimulated glucose uptake in palmitate‐induced insulin‐resistant C2C12 myotubes revealed that SesN2‐induced autophagy contributed to restore the impaired insulin signaling through the activation of AMPK signal.
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Effect of exercise and butyrate supplementation on microbiota composition and lipid metabolism.
TL;DR: The effect of exercise training and dietary supplementation of butyrate on the composition of gut microbiota and whether the altered gut microbiota can stimulate differential production of short-chain fatty acids (SCFAs) is examined to improve metabolic health and protect against obesity.