Li C. Yan
Northeast Normal University
5 Papers
38 Citations
Li C. Yan is an academic researcher from Northeast Normal University. The author has contributed to research in topics: Acute toxicity & Toxicity. The author has an hindex of 4, co-authored 5 publications.
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Papers
Relationship between acute and chronic toxicity for prevalent organic pollutants in Vibrio fischeri based upon chemical mode of action
Xiao H. Wang,Ling Y. Fan,Shuo Wang,Yue Wang,Li C. Yan,Shan S. Zheng,Christopher J. Martyniuk,Yuan H. Zhao +7 more
TL;DR: Toxicity data for Vibrio fischeri involving 52 compounds for acute and chronic toxicity were used to determine the congruence of acute and Chronic toxicity for assessing MOAs, with pronounced differences for the antibiotics due to the difference in bioconcentration.
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Comparison of modes of action among different trophic levels of aquatic organisms for pesticides and medications based on interspecies correlations and excess toxicity: Theoretical consideration.
TL;DR: T theoretical equations of interspecies relationship and excess toxicity have been developed and used to investigate the MOAs among fish, Daphnia magna, Tetrahymena pyriformis and Vibrio fischeri for pesticides and medications and suggested that fungicides, herbicides and medications share the similarMOAs among the four species.
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The impact of exposure route for class-based compounds: a comparative approach of lethal toxicity data in rodent models.
TL;DR: In this article, the relationship of toxicities from intravenous (i.v.), intraperitoneal (ip), subcutaneous (s.c.), and intragastric exposure routes to mice were investigated.
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Comparison of modes of action between fish and zebrafish embryo toxicity for baseline, less inert, reactive and specifically-acting compounds.
TL;DR: The toxicity significantly related with the chemical hydrophobicity for baseline and less inert compounds, respectively, indicates that these two classes of compounds share the same MOAs between fish and embryos.
6
Toxicity of some prevalent organic chemicals to tadpoles and comparison with toxicity to fish based on mode of toxic action.
TL;DR: Quantitative structure-activity relationship (QSAR) showed that toxicity to tadpoles is closely related to the chemical octanol/water partition coefficient, energy of the lowest unoccupied molecular orbital (ELUMO), and number of hydrogen bond donors and acceptors (NHDA), representing the bio-uptake potential in tadpole, the electrophilicity and hydrogen bonding capacity with target site(s), respectively.