Leyuan Wang
Central South University
22 Papers
36 Citations
Leyuan Wang is an academic researcher from Central South University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 6, co-authored 16 publications.
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Papers
Assessment of Endovascular Treatment for Acute Basilar Artery Occlusion via a Nationwide Prospective Registry
Wenjie Zi,Zhongming Qiu,Deping Wu,Fengli Li,Hansheng Liu,Wenhua Liu,Wenguo Huang,Zhonghua Shi,Yongjie Bai,Zhensheng Liu,Li Wang,Shiquan Yang,Jie Pu,Changming Wen,Shouchun Wang,Qiyi Zhu,Wenhuo Chen,Congguo Yin,Min Lin,Li Qi,Yaoyi Zhong,Zhen Wang,Wenjun Wu,Huisheng Chen,Xiaoxi Yao,Feng Xiong,Guoyong Zeng,Zhiming Zhou,Zhilin Wu,Yue Wan,Huiyuan Peng,Bing Li,Xinping Hu,Hongbin Wen,Wangtao Zhong,Leyuan Wang,Ping Jin,Fuqiang Guo,Ju Han,Xinmin Fu,Zhibing Ai,Xiguang Tian,Xiaoya Feng,Bo Sun,Zhizhi Huang,Wei Li,Peiyang Zhou,Mingyi Tu,Xiangrong Sun,Hua Li,Wencheng He,Tao Qiu,Zhengzhou Yuan,Chengsong Yue,Jun Yang,Weidong Luo,Zili Gong,Jie Shuai,Raul G Nogueira,Qingwu Yang +59 more
TL;DR: Among patients with acute BAO, EVT administered within 24 hours of estimated occlusion time is associated with better functional outcomes and reduced mortality, and this nonrandomized cohort study was a nationwide prospective registry of consecutive patients presenting with an acute, symptomatic, radiologically confirmed BAO to 47 comprehensive stroke centers in China.
ITGB4 deficiency induces senescence of airway epithelial cells through p53 activation
Lin Yuan,Xizi Du,Sha Tang,Shuangyan Wu,Leyuan Wang,Yang Xiang,Xiangping Qu,Huijun Liu,Xiaoqun Qin,Chi Liu +9 more
TL;DR: It is shown that ITGB4 deficiency induces the senescence of airway epithelial cells through the activation of the p53 pathway both in vitro and in vivo and may be involved in the pathogenesis of asthma.
41
Airway epithelial integrin β4 suppresses allergic inflammation by decreasing CCL17 production.
Lin Yuan,Xun Zhang,Ming Yang,Ming Yang,Xizi Du,Leyuan Wang,Shuangyan Wu,Mengping Wu,Zhen Duan,Gelei Xiao,Yizhou Zou,Yang Xiang,Xiangping Qu,Huijun Liu,Ling Qin,Qingwu Qin,Xiaoqun Qin,Chi Liu +17 more
TL;DR: The involvement of ITGB4 deficiency in the development of Th2 responses of allergic asthma by down-regulation of EGFR and CCL17 pathway in AECs is demonstrated.
17
Airway epithelial ITGB4 deficiency in early life mediates pulmonary spontaneous inflammation and enhanced allergic immune response
Sha Tang,Xizi Du,Lin Yuan,Gelei Xiao,Mengping Wu,Leyuan Wang,Shuangyan Wu,Zhen Duan,Yang Xiang,Xiangping Qu,Huijun Liu,Yizhou Zou,Xiaoqun Qin,Ling Qin,Chi Liu +14 more
TL;DR: It is demonstrated that ITGB4 deficiency following birth mediates spontaneous lung inflammation with ILC2 activation and increased infiltration of eosinophils and lymphocytes and induces exaggerated lung inflammation response to HDM aeroallergen.
17
The DNA methylation of FOXO3 and TP53 as a blood biomarker of late-onset asthma.
Lin Yuan,Leyuan Wang,Xizi Du,Ling Qin,Ming Yang,Kai Zhou,Mengping Wu,Yu Yang,Zhiyuan Zheng,Yang Xiang,Xiangping Qu,Huijun Liu,Xiaoqun Qin,Chi Liu +13 more
TL;DR: Forkhead Box O3 and TP53 methylation is a suitable blood biomarker to predict LOA, which may be useful targets for the risk diagnosis and clinical management of LOA.