Leszek Helczynski
Lund University
15 Papers
43 Citations
Leszek Helczynski is an academic researcher from Lund University. The author has contributed to research in topics: Prostate cancer & Prostate. The author has an hindex of 11, co-authored 15 publications.
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Papers
Carbon Monoxide Expedites Metabolic Exhaustion to Inhibit Tumor Growth
Barbara Wegiel,David Gallo,Eva Csizmadia,Clair Harris,John D. Belcher,Gregory M. Vercellotti,Nuno Penacho,Pankaj Seth,Vikas P. Sukhatme,Asif Ahmed,Pier Paolo Pandolfi,Leszek Helczynski,Anders Bjartell,Jenny L. Persson,Leo E. Otterbein +14 more
TL;DR: It is indicated that CO transiently induces an anti-Warburg effect by rapidly fueling cancer cell bioenergetics, ultimately resulting in metabolic exhaustion.
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The lysine specific demethylase-1 (LSD1/KDM1A) regulates VEGF-A expression in prostate cancer.
Vasundhra Kashyap,Shafqat Ahmad,Emeli M. Nilsson,Leszek Helczynski,Sinéad Kenna,Jenny L. Persson,Lorraine J. Gudas,Nigel P. Mongan,Nigel P. Mongan +8 more
TL;DR: It is demonstrated that pharmacological inhibition of LSD1 reduces proliferation of both androgen dependent and independent cell lines (LnCaP: C42, PC3) and shows a direct mechanistic link between LSD1 over‐expression and increased activity of pro‐angiogenic pathways.
95
Cartilage oligomeric matrix protein promotes prostate cancer progression by enhancing invasion and disrupting intracellular calcium homeostasis
Emelie Englund,Giacomo Canesin,Konstantinos S. Papadakos,Neelanjan Vishnu,Emma Persson,Bart Reitsma,Aseem Anand,Laila Jacobsson,Leszek Helczynski,Hindrik Mulder,Anders Bjartell,Anna M. Blom +11 more
TL;DR: Cartilage oligomeric matrix protein is a potent driver of the progression of prostate cancer, acting in an anti-apoptotic fashion by interfering with the Ca2+ homeostasis of cancer cells.
55
Automatic registration of multi-modal microscopy images for integrative analysis of prostate tissue sections
TL;DR: The proposed method is both reliable and fast and therefore well suited for automatic segmentation and analysis of specific areas of interest, combining morphological information with protein expression data from three consecutive tissue sections.
Emphasizing the role of Wnt5a protein expression to predict favorable outcome after radical prostatectomy in patients with low-grade prostate cancer
Azharuddin Sajid Syed Khaja,Lars Egevad,Leszek Helczynski,Peter Wiklund,Tommy Andersson,Anders Bjartell +5 more
TL;DR: It is shown that preserved overexpression of Wnt5a protein is associated with increased time to biochemical recurrence in localized low‐grade prostate cancer patients after radical prostatectomy, emphasizing that Wnt 5a can be used as a predictive biomarker, and favoring the view of Wtsn5a as a future therapeutic target in prostate cancer Patients with tumor cells displaying low expression of WNT5a.