Several 4-substituted 1-acylpiperazines, obtained by molecular simplification of 4-substituted 1,4-diazabicyclo[4.3.0]nonan-9-ones, have been synthesized and tested in vivo on the mouse passive avoidance test, to evaluate their nootropic activity. The results show that, apparently, an N-acylpiperazine group can mimic the 2-pyrrolidinone ring of 1,4-diazabicyclo[4.3.0]nonan-9-one, as the compounds of the new series maintain high nootropic activity. Moreover molecular simplification produces more clear-cut structure−activity relationships with respect to the parent series. The mechanism of action also appears to be similar in the two series. In fact, although the molecular mechanism remains to be elucidated, the most potent compound of each class (DM232 and 13, DM235) is able to increase acetylcholine release in rat brain. Piperazine derivatives represent a new class of nootropic drugs with an in vivo pharmacological profile very similar to that of piracetam, showing much higher potency with respect to the ...

/pdf/molecular-simplification-of-1-4-diazabicyclo-4-3-0-nonan-9-29yguiyjh7.pdf

Molecular simplification of 1,4-diazabicyclo[4.3.0]nonan-9-ones gives piperazine derivatives that maintain high nootropic activity.

In view of their herbicidal properties a number of 2-(substituted amino) −4,6-dichloro-1,3,5-triazines was synthesized by a method described in the literature. The influence of the side chain on the herbicidal properties was determined. For this reason some derivatives mentioned in the literature were included to compare them with the new compounds in our biological tests.

Investigations on herbicides I. 2‐(Substituted amino)‐4,6‐dichloro‐1,3,5‐triazines

10 – Chemotherapy of Amebiasis

Reactions of Benzenesulfonohydrazides and Benzenesulfonamides with Hydrogen Chloride or Hydrogen Bromide in Acetic Acid

Preparation on N‐[2‐Chloro‐4‐diethylamino‐1,3,5‐triazin‐6‐yl)]‐amino Acids

Antineoplastika, 19. Mitt.: Darstellung von N‐[2‐Chlor‐4‐diethylamino‐(1,3,5‐triazin‐6‐yl)]‐aminosäuren

Cyanuric chloride has been condensed with glycine and 0-alanine esters to give a series of amino ester derivatives of the s-triazine ring. 2,4,6-Tris-(carbethoxyalkyl) derivatives could not be formed in aqueous media, nor could condensation with urethan be effected. Biological activities of these and other triazines are described.

Amine derivatives of cyanuric chloride. II. amino esters.

Notes - Preparation of Mono-N-alkyl and -N-Acyl Piperazines by Non hydrolytic Cleavage of 1-Carbethoxypiperazines

Handle everyday research tasks with reliable, citation-backed results

Your personal Research Agent to handle research tasks with citation-backed results

Popular Tasks used by Researchers

How can I help with your research?

Meet SciSpace

Get more enhanced response by uploading the PDFs you want me to reference.

No relevant PDFs in your library

SciSpace is the AI research assistant for academics. Run systematic literature reviews on 280M+ papers, and write papers with cited sources. Trusted by 1M+ students, PhDs & researchers.

SciSpace | AI for Research

Analyze PDFs

Code & Manuscripts

Funding & Grants

Literature & Patents

Medical & Clinical Data

Systematic Review

Visualize & Present

Web & Data

Build a Google Scholar-like website for your research.

Build a website

Create charts and images for your research

Create a Chart

Write a paper for submission to a journal

Draft a manuscript

Patent Search

Design eye-catching scientific posters in minutes.

Scientific Poster Generation

Systematic Literature Review

One task is running at the moment. Your messages will be shown right after.

Drag and drop or click here to browse

Loved by <highlight>1 million+</highlight> researchers

Extract a list of specific topics and their sources from unstructured text

Topics

Compare and analyze relevant papers that matches with your search

Papers

Get insights from PDFs and bookmarked papers from your library

My library

Recent searches

Try searching for:

Catch AI-generated content in scholarly and non-scholarly content

{ai} Detector

Ai Writer

Get PDF Summaries, highlighted text explanations 

Chat with PDF

Effortlessly create in-text citations and bibliographies in APA and 2,500 other formats

Citation generator

Get explanations, summaries, and answers on academic papers

Ease up your research workflow with {scispace}'s cohort of exciting AI tools

Elevate your academic writing skills and convey your ideas the way you want

Paraphraser

Explore our range of reading and writing tools

Your file is being prepared and should be ready in a few minutes. If it's a large file, it might take a bit longer. You can close this window, and we'll email you the file when it's done.

You have reached a maximum limit of <strong>{limit}</strong> columns in the table. Remove at least <strong>1</strong> column to add or create another one.

Lester Chafetz

Author Tools

Chat about Author

Papers

Amine derivatives of cyanuric chloride. II. amino esters.

Notes - Preparation of Mono-N-alkyl and -N-Acyl Piperazines by Non hydrolytic Cleavage of 1-Carbethoxypiperazines