Leslie Chang
Johns Hopkins University
13 Papers
39 Citations
Leslie Chang is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Mesenchymal stem cell & Stromal cell. The author has an hindex of 5, co-authored 13 publications. Previous affiliations of Leslie Chang include University of California, San Diego.
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Papers
Fracture repair requires TrkA signaling by skeletal sensory nerves.
Zhu Li,Zhu Li,Carolyn A. Meyers,Leslie Chang,Seungyong Lee,Zhi Li,Ryan E. Tomlinson,Ahmet Hoke,Thomas L. Clemens,Thomas L. Clemens,Aaron W. James +10 more
TL;DR: An essential role of TrkA signaling for stress fracture repair is demonstrated and skeletal sensory nerves are implicate as an important upstream mediator of this repair process.
Human perivascular stem cell-derived extracellular vesicles mediate bone repair
Jiajia Xu,Yiyun Wang,Ching Yun Hsu,Yongxing Gao,Carolyn A. Meyers,Leslie Chang,Leititia Zhang,Leititia Zhang,Kristen P. Broderick,Catherine Ding,Bruno Péault,Bruno Péault,Kenneth W. Witwer,Aaron W. James +13 more
TL;DR: PSC-EVs mediate the same tissue repair effects of perivascular stem cells, and represent an ‘off-the-shelf’ alternative for bone tissue regeneration.
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A Neurotrophic Mechanism Directs Sensory Nerve Transit in Cranial Bone.
Carolyn A. Meyers,Seungyong Lee,Takashi Sono,Jiajia Xu,Stefano Negri,Stefano Negri,Ye Tian,Yiyun Wang,Zhu Li,Zhu Li,Sarah Miller,Leslie Chang,Yongxing Gao,Liliana Minichiello,Thomas L. Clemens,Thomas L. Clemens,Aaron W. James +16 more
TL;DR: An essential role of NGF-TrkA signaling in bone healing is demonstrated and macrophage-derived N GF-induced ingrowth of skeletal sensory nerves as an important mediator of this repair is implicate.
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Pericytes for Therapeutic Bone Repair.
Carolyn A. Meyers,Joan Casamitjana,Leslie Chang,Lei Zhang,Aaron W. James,Aaron W. James,Bruno Péault +6 more
TL;DR: Using diverse bone formation assays in vivo, which include mouse muscle pocket osteogenesis and calvaria replenishment, rat and dog spine fusion, and rat non-union fracture healing, has confirmed the superiority of purified perivascular cells for skeletal (re)generation.
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Lysosomal protein surface expression discriminates fat- from bone-forming human mesenchymal precursor cells.
Jiajia Xu,Yiyun Wang,Ching Yun Hsu,Stefano Negri,Robert J. Tower,Yongxing Gao,Ye Tian,Ye Tian,Takashi Sono,Carolyn A. Meyers,Winters R. Hardy,Winters R. Hardy,Leslie Chang,Shuaishuai Hu,Nusrat Kahn,Kristen P. Broderick,Bruno Péault,Bruno Péault,Aaron W. James,Aaron W. James +19 more
TL;DR: Results document the molecular and functional diversity of perivascular regenerative cells, and show that relocation to cell surface of a lysosomal protein marks the transition from osteo- to adipogenic potential in native human MSCs, a population of substantial therapeutic interest.
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