Les Bluck
MRC Human Nutrition Research
38 Papers
163 Citations
Les Bluck is an academic researcher from MRC Human Nutrition Research. The author has contributed to research in topics: Insulin resistance & Insulin. The author has an hindex of 17, co-authored 38 publications. Previous affiliations of Les Bluck include University of Reading & Medical Research Council.
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Papers
Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis
Robert K. Semple,Alison Sleigh,Peter R. Murgatroyd,Claire Adams,Les Bluck,Sarah Jackson,Alessandra Vottero,Dipak Kanabar,Valentine Charlton-Menys,Paul N. Durrington,Maria A. Soos,T. Adrian Carpenter,David J. Lomas,Elaine Cochran,Phillip Gorden,Stephen O'Rahilly,David B. Savage +16 more
TL;DR: Data from humans with molecularly characterized forms of insulin resistance suggest that partial postreceptor hepatic insulin resistance is a key element in the development of metabolic dyslipidemia and hepatic steatosis.
Estimation of daily energy expenditure in pregnant and non-pregnant women using a wrist-worn tri-axial accelerometer.
Vincent T. van Hees,Frida Renström,Frida Renström,Antony Wright,Anna Gradmark,Michael Catt,Kong Y. Chen,Marie Löf,Les Bluck,Jeremy Pomeroy,Nicholas J. Wareham,Ulf Ekelund,Soren Brage,Paul W. Franks,Paul W. Franks +14 more
TL;DR: A simple summary measure derived from a wrist-worn tri-axial accelerometer adds significantly to the prediction of energy expenditure in non-pregnant women and is scored acceptable by participants.
Effect of changing the amount and type of fat and carbohydrate on insulin sensitivity and cardiovascular risk: the RISCK (Reading, Imperial, Surrey, Cambridge, and Kings) trial
Susan A. Jebb,Julie A. Lovegrove,Bruce A. Griffin,Gary Frost,Carmel Moore,Mark D. Chatfield,Les Bluck,Christine M. Williams,Thomas A. B. Sanders +8 more
TL;DR: This study did not support the hypothesis that isoenergetic replacement of SFAs with MUFAs or carbohydrates has a favorable effect on Si, and lowering GI enhanced reductions in TC and LDL-cholesterol concentrations in subjects, with tentative evidence of improvements in Si in the LF-treatment group.
205
Extraction and Quantification of Daidzein and Genistein in Food
TL;DR: A simple analytical method has been developed for routine quantification of a broad range of concentrations of the isoflavones daidzein and genistein in food by comparison with authentic synthetic standards using gas chromatography-mass spectrometry in selected ion mode.
109
Physical activity, sedentary behaviors, and estimated insulin sensitivity and secretion in pregnant and non-pregnant women
Anna Gradmark,Jeremy Pomeroy,Jeremy Pomeroy,Jeremy Pomeroy,Frida Renström,Frida Renström,Frida Renström,Susanne Steiginga,Margareta Persson,Antony Wright,Les Bluck,Magnus Domellöf,Steven E. Kahn,Ingrid Mogren,Paul W. Franks,Paul W. Franks,Paul W. Franks +16 more
TL;DR: It is suggested that physical activity conveys similar benefits on glucose homeostasis in pregnant and non-pregnant women, despite differences in subcomponents of physical activity.