Leroy Hood
Institute for Systems Biology
881 Papers
22.7K Citations
Leroy Hood is an academic researcher from Institute for Systems Biology. The author has contributed to research in topics: Gene & Biology. The author has an hindex of 158, co-authored 853 publications. Previous affiliations of Leroy Hood include Agency for Science, Technology and Research & Stowers Institute for Medical Research.
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Papers
Thiobenzoylation Method of Protein Sequencing: Gas Chromatography/Mass Spectrometric Detection of 5-Acetoxy-2-Phenylthiazoles
Mark L. Stolowitz,Chin-Sook Kim,Steven R. Marsh,Leroy Hood +3 more
- 01 Jan 1993
TL;DR: Stolowitz et al. as mentioned in this paper recently reexamined this approach utilizing a capillary gas chromatography/mass spectrometry system and found the method to exhibit considerable potential, but their efforts to further develop the thiobenzoylation method have been somewhat hindered by the limited reactivity of thioacetylating reagents and difficulties encountered in the synthesis of the amino acid derivatives for use as analytical standards.
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Atlas of Transcription Factor Binding Sites from ENCODE DNase Hypersensitivity Data Across 27 Tissue Types
Cory C. Funk,Segun Jung,Matthew A. Richards,Alex Rodriguez,Paul Shannon,Rory Donovan,Ben Heavner,Kyle Chard,Yukai Xiao,Gustavo Glusman,Nilufer Erteskin-Taner,Todd E. Golde,Arthur W. Toga,Leroy Hood,John D. Van Horn,Carl Kesselman,Ian Foster,Seth A. Ament,Ravi Madduri,Nathan D. Price +19 more
TL;DR: This work implemented a workflow for uniform processing of footprints using two state-of-the-art footprinting algorithms: Wellington and HINT, and applied this workflow to detect footprints in 192 DNase-seq experiments from ENCODE spanning 27 human tissues, resulting in high-quality footprints covering 9.8% of the human genome.
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High-Throughput cDNA Screening Utilizing a Low Order Neural Network Filter
TL;DR: A low order neural network-based filter was designed as a rapid screening agent for single-spanning transmembrane regions in an integrated informatics system and yielded 13 homologs in the predicted reading frame, four of which are membrane associated.
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Human lymphoblastoid interferon: purification, amino acid composition, and amino-terminal sequence
Kathryn C. Zoon,Mark E. Smith,Pamela J. Bridgen,Dorothy Zur Nedden,Dorothea M. Miller,Christian B. Anfinsen,Michael W. Hunkapiller,Leroy Hood +7 more
TL;DR: Through this collaboration, Anfinsen's lab developed a microsequencer, a technology that allowed them to obtain amino acid sequence data on 10 to 20 picomoles of protein and were able to successfully determine the amino-terminal amino acids sequence of the major component of human lymphoblastoid interferon (HuIFN-alpha).
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