Lepei Chen
Shanghai Jiao Tong University
4 Papers
6 Citations
Lepei Chen is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Nanocarriers & Drug delivery. The author has an hindex of 3, co-authored 4 publications.
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Papers
Lipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to Ras -activated glioblastoma cells via macropinocytosis
Jialin Huang,Gan Jiang,Qingxiang Song,Xiao Gu,Meng Hu,Xiaolin Wang,Huahua Song,Lepei Chen,Yingying Lin,Di Jiang,Jun Chen,Junfeng Feng,Yongming Qiu,Jiyao Jiang,Xinguo Jiang,Hong-Zhuan Chen,Xiaoling Gao +16 more
TL;DR: A biologically inspired nanostructure that can induce cancer cells to ‘drink drugs' for targeting activating transcription factor-5 (ATF5), an overexpressed anti-apoptotic transcription factor in glioblastoma and other Ras-activated cancers is created.
Tailored Reconstituted Lipoprotein for Site-Specific and Mitochondria-Targeted Cyclosporine A Delivery to Treat Traumatic Brain Injury.
Lepei Chen,Qingxiang Song,Yaoxing Chen,Shuang Meng,Mengna Zheng,Jialin Huang,Qian Zhang,Jiyao Jiang,Junfeng Feng,Hong-Zhuan Chen,Hong-Zhuan Chen,Gan Jiang,Xiaoling Gao +12 more
TL;DR: Strong evidence is provided that the secondary damages in TBI can be well controlled through targeted CsA delivery, and the potential of lipoprotein biomimetic nanocarrier as a flexible nanoplatform for the management of TBI is highlighted.
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The shape effect of reconstituted high-density lipoprotein nanocarriers on brain delivery and Aβ clearance
Huahua Song,Xinyi Ma,Jianrong Xu,Qingxiang Song,Meng Hu,Xiao Gu,Qian Zhang,Lina Hou,Lepei Chen,Yukun Huang,Ping Yu,Dayuan Wang,Gan Jiang,Meng Huang,Jun Chen,Hong-Zhuan Chen,Xiaoling Gao +16 more
TL;DR: Spherical rHDL had stronger Aβ-binding affinity than discoidal r HDL did, more effectively facilitated microglial uptake and degradation of Aβ1–42, achieved better brain distribution after intravenous administration, and more powerfully reduced Aβ deposition, decreased microglia activation, attenuated neurological damage, and rescued memory deficits in a mouse model of AD.
8
Patent
Lipid nano drug delivery system targeting brain lesion and preparation method and application thereof
Xiaoling Gao,Qingxiang Song,Gan Jiang,Lepei Chen +3 more
- 27 May 2021
TL;DR: In this paper, a lipid nano drug delivery system targeting a brain lesion and a preparation method and application thereof is presented, which consists of a lipid, a delivery drug, and a functional penetrating peptide, formed by covalently connecting a peptide chain linking a nanocarrier end.