Leonie Jestaedt
Heidelberg University
14 Papers
47 Citations
Leonie Jestaedt is an academic researcher from Heidelberg University. The author has contributed to research in topics: Magnetic resonance imaging & Aneurysm. The author has an hindex of 12, co-authored 14 publications. Previous affiliations of Leonie Jestaedt include University Hospital Heidelberg & Bayer Schering Pharma AG.
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Papers
An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor
Christiane A. Opitz,Ulrike M. Litzenburger,Ulrike M. Litzenburger,Felix Sahm,Martina Ott,Isabel Tritschler,Saskia Trump,Theresa Schumacher,Theresa Schumacher,Leonie Jestaedt,Dieter Schrenk,Michael Weller,Manfred Jugold,Gilles J. Guillemin,Christine L. Miller,Christian Lutz,Bernhard Radlwimmer,Irina Lehmann,Andreas von Deimling,Wolfgang Wick,Michael Platten +20 more
TL;DR: Evidence is provided for a previously unidentified pathophysiological function of the AHR that is constitutively generated by human tumours via tryptophan-2,3-dioxygenase (TDO), a liver- and neuron-derived Trp-degrading enzyme not yet implicated in cancer biology.
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The FRED flow-diverter stent for intracranial aneurysms: clinical study to assess safety and efficacy.
Markus A Möhlenbruch,Christian Herweh,Leonie Jestaedt,Sibylle Stampfl,Silvia Schönenberger,Peter A. Ringleb,Martin Bendszus,Mirko Pham +7 more
TL;DR: Deployment of the Flow-Redirection Intraluminal Device flow-diverter stent is safe and effective in the treatment of difficult-to-treat or otherwise untreatable intracranial aneurysms.
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Gadofluorine M enhancement allows more sensitive detection of inflammatory CNS lesions than T2-w imaging: a quantitative MRI study.
Martin Bendszus,Gesa Ladewig,Leonie Jestaedt,Bernd Misselwitz,Laszlo Solymosi,Klaus Toyka,Guido Stoll +6 more
TL;DR: Application of the experimental magnetic resonance-contrast agent Gadofluorine M significantly increased the sensitivity of lesion detection in myelin-oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis, an animal model for multiple sclerosis.
54
Primary glioblastoma cultures: can profiling of stem cell markers predict radiotherapy sensitivity?
Dieter Lemke,Dieter Lemke,Markus Weiler,Markus Weiler,Jonas Blaes,Benedikt Wiestler,Benedikt Wiestler,Leonie Jestaedt,Ann Catherine Klein,Sarah Löw,Sarah Löw,Günter Eisele,Bernhard Radlwimmer,David Capper,Kirsten Schmieder,Michel Mittelbronn,Michel Mittelbronn,Stephanie E. Combs,Martin Bendszus,Michael Weller,Michael Platten,Wolfgang Wick,Wolfgang Wick +22 more
TL;DR: Established stem cell markers and stem cell attributed characteristics such as self‐renewal capacity and tumorigenicity have been profiled in primary glioblastoma cultures to predict radiosensitivity and, except CD44, the testedstem cell markers showed an inverse correlation between expression and radioresistance.
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Glioma cell VEGFR-2 confers resistance to chemotherapeutic and antiangiogenic treatments in PTEN-deficient glioblastoma
Tobias Kessler,Felix Sahm,Felix Sahm,Jonas Blaes,Matthias Osswald,Matthias Osswald,Petra Rübmann,David Milford,Severino Urban,Leonie Jestaedt,Sabine Heiland,Martin Bendszus,Anne Hertenstein,Anne Hertenstein,Philipp Niclas Pfenning,Carmen Ruiz de Almodovar,Antje Wick,Frank Winkler,Frank Winkler,Andreas von Deimling,Andreas von Deimling,Michael Platten,Michael Platten,Wolfgang Wick,Wolfgang Wick,Markus Weiler,Markus Weiler +26 more
TL;DR: Conclusively, expression of VEGFR-2 in glioma cells indicates an aggressive glioblastoma subgroup developing early resistance to temozolomide or bevacizumab.