Leonarda D'Angelo
University of Bologna
6 Papers
16 Citations
Leonarda D'Angelo is an academic researcher from University of Bologna. The author has contributed to research in topics: Wnt signaling pathway & Colorectal cancer. The author has an hindex of 5, co-authored 6 publications.
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Papers
Inflammation increases NOTCH1 activity via MMP9 and is counteracted by Eicosapentaenoic Acid-free fatty acid in colon cancer cells
Chiara Fazio,Giulia Piazzi,Paola Vitaglione,Vincenzo Fogliano,Alessandra Munarini,Anna Prossomariti,Maddalena Milazzo,Leonarda D'Angelo,Manuela Napolitano,Pasquale Chieco,Andrea Belluzzi,Franco Bazzoli,Luigi Ricciardiello +12 more
TL;DR: It is shown that a non-cytotoxic pre-treatment with EPA-FFA antagonizes the effect of inflammation on NOTCH1 signalling, with reduction of MMP9 activity and invasiveness, and that this mechanism can be counteracted by EPA- FFA.
A combination of eicosapentaenoic acid-free fatty acid, epigallocatechin-3-gallate and proanthocyanidins has a strong effect on mTOR signaling in colorectal cancer cells.
Leonarda D'Angelo,Giulia Piazzi,Annalisa Pacilli,Anna Prossomariti,Chiara Fazio,Lorenzo Montanaro,Giulia Graziani,Vincenzo Fogliano,Alessandra Munarini,Francesca Bianchi,Andrea Belluzzi,Franco Bazzoli,Luigi Ricciardiello +12 more
TL;DR: The data suggest that the low cytotoxic combination of EPA-FFA, EGCG and GS extract, tested for the first time here, inhibits mTOR signaling and thus could be considered for CRC treatment.
Van-Gogh-like 2 antagonises the canonical WNT pathway and is methylated in colorectal cancers.
Giulia Piazzi,Giulia Piazzi,Michael Selgrad,Michael Selgrad,Melissa Garcia,Claudio Ceccarelli,Lucia Fini,Paolo Bianchi,Luigi Laghi,Leonarda D'Angelo,Paola Paterini,Peter Malfertheiner,Pasquale Chieco,Clement Richard Boland,Franco Bazzoli,Luigi Ricciardiello,Luigi Ricciardiello +16 more
TL;DR: Van-Gogh-like 2 is frequently methylated in MSI-CRCs with BRAF mutation and may act as a tumour suppressor gene, counteracting WNT/β-catenin signaling.
miR-155 Is Downregulated in Familial Adenomatous Polyposis and Modulates WNT Signaling by Targeting AXIN1 and TCF4
Anna Prossomariti,Giulia Piazzi,Leonarda D'Angelo,Sara Miccoli,Daniela Turchetti,Chiara Alquati,Claudio Montagna,Franco Bazzoli,Luigi Ricciardiello +8 more
TL;DR: This study supports a key role of miR-155-5p in modulating WNT/β-CATENIN signaling in colorectal cancer and unravels a new mechanism for AXIN1 regulation which represents a potential therapeutic target in specific tumor subtypes.