174 Papers
311 Citations
Leng Han is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 50, co-authored 149 publications. Previous affiliations of Leng Han include Kunming Institute of Zoology & University of Texas at Austin.
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Papers
Comprehensive characterization of tissue-specific circular RNAs in the human and mouse genomes
Siyu Xia,Jing Feng,Lijun Lei,Jun Hu,Linjian Xia,Jun Wang,Yu Xiang,Lingjun Liu,Shan Zhong,Leng Han,Chunjiang He +10 more
TL;DR: This study is the first comprehensive view of TS circRNAs in human and mouse, which shed light on circRNA functions in organ development and disorders.
YTHDF3 Induces the Translation of m6A-Enriched Gene Transcripts to Promote Breast Cancer Brain Metastasis
Guoqiang Chang,Lei Shi,Youqiong Ye,Hailing Shi,Hailing Shi,Lixian Zeng,Shweta Tiwary,Jason T. Huse,Lei Huo,Li Ma,Yongjie Ma,Sicong Zhang,Jianwei Zhu,Victoria Xie,Peng Li,Leng Han,Chuan He,Chuan He,Suyun Huang,Suyun Huang +19 more
TL;DR: This work uncovers an essential role of YTHDF3 in controlling the interaction between cancer cells and brain microenvironment, thereby inducing brain metastatic competence.
316
Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression.
Qingsong Hu,Youqiong Ye,Li Chuan Chan,Yajuan Li,Ke Liang,Aifu Lin,Aifu Lin,Sergey D. Egranov,Yaohua Zhang,Weiya Xia,Jing Gong,Yinghong Pan,Sujash S. Chatterjee,Jun Yao,Kurt W. Evans,Tina K. Nguyen,Peter K. Park,Jiewei Liu,Cristian Coarfa,Sri Ramya Donepudi,Vasanta Putluri,Nagireddy Putluri,Arun Sreekumar,Chandrashekar R. Ambati,David H. Hawke,Jeffrey R. Marks,Preethi H. Gunaratne,Preethi H. Gunaratne,Abigail S. Caudle,Aysegul A. Sahin,Gabriel N. Hortobagyi,Funda Meric-Bernstam,Lieping Chen,Dihua Yu,Mien Chie Hung,Michael A. Curran,Leng Han,Chunru Lin,Liuqing Yang +38 more
TL;DR: LncRNA-dependent downregulation of antigenicity and intrinsic tumor suppression is demonstrated, which provides the basis for developing combinational immunotherapy treatment regimens and early TNBC prevention.
306
Assessing the clinical utility of cancer genomic and proteomic data across tumor types
Yuan Yuan,Eliezer M. Van Allen,Eliezer M. Van Allen,Larsson Omberg,Nikhil Wagle,Nikhil Wagle,Ali Amin-Mansour,Artem Sokolov,Lauren Averett Byers,Yanxun Xu,Kenneth R. Hess,Lixia Diao,Leng Han,Xuelin Huang,Michael S. Lawrence,John N. Weinstein,Josh Stuart,Gordon B. Mills,Levi A. Garraway,Levi A. Garraway,Adam A. Margolin,Adam A. Margolin,Gad Getz,Gad Getz,Han Liang +24 more
TL;DR: It is found that incorporating molecular data with clinical variables yields statistically significantly improved predictions for three cancers but those quantitative gains were limited, and a starting point and resources are provided for building reliable prognostic and therapeutic strategies that incorporate molecular data.
A ROR1-HER3-lncRNA signalling axis modulates the Hippo-YAP pathway to regulate bone metastasis
Chunlai Li,Shouyu Wang,Zhen Xing,Aifu Lin,Ke Liang,Jian Song,Qingsong Hu,Jun Yao,Zhongyuan Chen,Zhongyuan Chen,Peter K. Park,David H. Hawke,Jianwei Zhou,Yan Zhou,Shuxing Zhang,Han Liang,Mien Chie Hung,Mien Chie Hung,Gary E. Gallick,Leng Han,Chunru Lin,Liuqing Yang +21 more
TL;DR: The data provide insights into the mechanistic regulation and linkage of the ROR1–HER3 and Hippo–YAP pathway in a cancer-specific context, and also imply valuable therapeutic targets for bone metastasis and possible therapy-resistant tumours.