174 Papers
311 Citations
Leng Han is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 50, co-authored 149 publications. Previous affiliations of Leng Han include Kunming Institute of Zoology & University of Texas at Austin.
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Papers
Association between Sex and Immune-Related Adverse Events during Immune Checkpoint Inhibitor Therapy
Ying Jing,Ying Jing,Yongchang Zhang,Jing Wang,Kunyan Li,Xue Chen,Jianfu Heng,Qian Gao,Youqiong Ye,Zhao Zhang,Yaoming Liu,Yanyan Lou,Steven H. Lin,Lixia Diao,Hong Liu,Xiang Chen,Gordon B. Mills,Leng Han,Leng Han +18 more
TL;DR: In this article, the authors performed a meta-analysis on published clinical study data and multivariable logistic regression on pharmacovigilance data and applied a propensity algorithm to The Cancer Genome Atlas omics data.
Maximizing the Utility of Cancer Transcriptomic Data.
TL;DR: Computational resources for deep mining of transcriptomic data to identify, quantify, and determine the functional effects and clinical utility of transcriptsomic events, including noncoding RNAs, post-transcriptional regulation, exogenousRNAs, and transcribed genetic variants are reviewed.
The Pan-Cancer analysis of pseudogene expression reveals biologically and clinically relevant tumour subtypes
Leng Han,Yuan Yuan,Siyuan Zheng,Yang Yang,Yang Yang,Jun Li,Mary E. Edgerton,Lixia Diao,Yanxun Xu,Roeland Verhaak,Han Liang +10 more
TL;DR: Across cancer types, the tumor subtypes revealed by pseudogene expression show extensive and strong concordance with the subtypes defined by other molecular data, and in kidney cancer, the pseudogene-expression subtypes not only significantly correlate with patient survival, but also help stratify patients in combination with clinical variables.
RNA Helicase DHX37 Facilitates Liver Cancer Progression by Cooperating with PLRG1 to Drive Superenhancer-Mediated Transcription of Cyclin D1
Zhen Liu,Youqiong Ye,Yizhe Liu,Yanfang Liu,Huifang Chen,Mengting Shen,Zhen Wang,Shenglin Huang,Leng Han,Zhiao Chen,Xianghuo He +10 more
TL;DR: A cooperative mechanistic interaction between DHX37 and PLRG1 that regulates CCND1 expression and promotes liver cancer progression is demonstrated, advancing the understanding of the epigenetic and transcriptional dysregulations mediated by RNA helicases and super enhancers in HCC.