174 Papers
311 Citations
Leng Han is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 50, co-authored 149 publications. Previous affiliations of Leng Han include Kunming Institute of Zoology & University of Texas at Austin.
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Papers
Genome-wide DNA methylation profiling in 40 breast cancer cell lines
Leng Han,Siyuan Zheng,Shuying Sun,Tim H M Huang,Zhongming Zhao +4 more
- 18 Aug 2010
TL;DR: A gene signature consisting of 345 differentially methylated genes, which could be used to discriminate estrogen receptor (ER)-negative and ERpositive breast cancer cell lines is identified, which is promising for diagnosis and therapies of breast cancer.
CircView: a visualization and exploration tool for circular RNAs.
Jing Feng,Yu Xiang,Siyu Xia,Huan Liu,Jun Wang,Fatma Muge Ozguc,Lijun Lei,Ruoshan Kong,Lixia Diao,Chunjiang He,Leng Han +10 more
TL;DR: This work introduces CircView, a user-friendly visualization tool for circRNAs detected from existing tools, which helps users to better understand potential functions of circ RNAs and design the functional experiments.
Mining diverse small RNA species in the deep transcriptome
TL;DR: A rationale to include all types of sRNAs in sRNA sequencing analyses is provided, which will aid in the discovery of their biological functions and physiological relevance.
Multi-omics prediction of immune-related adverse events during checkpoint immunotherapy
Ying Jing,Jin Liu,Youqiong Ye,Lei Pan,Hui Deng,Yushu Wang,Yang Yang,Lixia Diao,Steven H. Lin,Gordon B. Mills,Guanglei Zhuang,Xinying Xue,Leng Han +12 more
- 30 May 2024
TL;DR: This study combines pharmacovigilance and multi-omics data to identify biomarkers for immune-related adverse events in cancer patients undergoing checkpoint immunotherapy, discovering a predictive model involving LCP1 and ADPGK.
Escherichia coli Metabolite Profiling Leads to the Development of an RNA Interference Strain for Caenorhabditis elegans
Isaiah A.A. Neve,Jessica N. Sowa,Chih-Chun J Lin,Priya Sivaramakrishnan,Christophe Herman,Youqiong Ye,Leng Han,Meng C. Wang,Meng C. Wang +8 more
TL;DR: The importance of specific bacterial metabolites in regulating the host’s physiology is suggested, and an RNA interference competent OP50 (iOP50) strain is provided to prevent confounding effects when analyzing genotype-phenotype interactions under different bacterial backgrounds is suggested.