174 Papers
311 Citations
Leng Han is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 50, co-authored 149 publications. Previous affiliations of Leng Han include Kunming Institute of Zoology & University of Texas at Austin.
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Papers
Resolving Spliceosomal Malfunctions Advances RNA-Based Therapeutics
Zhao Zhang,Shengli Li,Leng Han +2 more
TL;DR: Recent studies have identified recurrent spliceosomal mutations that induced genome-wide splicing alterations of cancer-related genes to promote malignancy, and suggest novel RNA-based therapeutics in anticancer treatment.
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Schizophrenia Genes: Characteristics of Function and Protein Interaction Networks
Jingchun Sun,Leng Han,Zhongming Zhao +2 more
- 27 May 2008
TL;DR: It is revealed that SCZ Genes have strong correlation with neurodevelopment and other functional term and the topological characteristics of SCZGenes in the human protein interaction network are found.
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Identification of a STIM1 Splicing Variant that Promotes Glioblastoma Growth (Adv. Sci. 11/2022)
Jiansheng Xie,Guolin Ma,Lijuan Zhou,Lin He,Zhao Zhang,Peng Tan,Zixian Huang,Shaohai Fang,Tianlu Wang,Yi-Tsang Lee,Shufan Wen,Stefan Siwko,Liuqing Wang,Jindou Liu,Yangchun Du,Ningxia Zhang,Xiaoxuan Liu,Leng Han,Yu Huang,Rui Wang,Youjun Wang,Yubin Zhou,Wei Han +22 more
TL;DR: Compared to pan‐STIM inhibition that tends to cause undesired immunosuppressive effects, targeting STIM1β might offer a solution for more precise glioblastoma intervention.
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Corrigendum: Antagonistic actions of two human Pan3 isoforms on global mRNA turnover.
TL;DR: This corrigendum is submitted to correct a few minor errors and add more detail about the bioinformatics method for mRNA half-life analysis in this paper.
Pathway and Network Analysis of Schizophrenia Candidate Genes under Meta-Analysis Linkage Peaks
Peilin Jia,Jingchun Sun,Leng Han,Zhongming Zhao +3 more
- 03 Aug 2009
TL;DR: The results indicated that these schizophrenia candidate genes involve in important functions such as receptor activity, transcriptional regulation, neurobiological and signaling pathways, which support the neurotransmitter and neuroplasticity theories of schizophrenia.
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