174 Papers
311 Citations
Leng Han is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 50, co-authored 149 publications. Previous affiliations of Leng Han include Kunming Institute of Zoology & University of Texas at Austin.
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Papers
Molecular Treasures of Cancer Cell Lines.
Shengli Li,Zhao Zhang,Leng Han +2 more
TL;DR: The expanded Cancer Cell Line Encyclopedia (CCLE), which spans the genome, transcriptome, epigenome, proteome and metabolome, thereby providing copious resources for cancer research, is described.
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RNA editing in cancer: Mechanistic, prognostic, and therapeutic implications
TL;DR: It is demonstrated that RNA editing can selectively affect cancer drug sensitivity and mechanistic, prognostic, and therapeutic implications for RNA editing in cancer are unveiled.
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ADEIP: an integrated platform of age-dependent expression and immune profiles across human tissues.
Xuan Liu,Wenbo Chen,Yu Fang,Siqi Yang,Liuping Chang,Xingyu Chen,Haidong Ye,Xinyu Tang,Shan Zhong,Wen Zhang,Zhiqiang Dong,Leng Han,Chunjiang He,Chunjiang He +13 more
TL;DR: Zhang et al. as mentioned in this paper developed a platform named ADEIP (http://gb.whu.edu.cn/ADEIP or http://geneyun.net/adeIP), integrating the age-dependent gene expression and immune profiles across tissues.
3D Spheroids Propel Tumor Characterization.
Shengli Li,Zhao Zhang,Leng Han +2 more
TL;DR: Large-scale clustered regularly interspaced short palindromic repeats screening in 3D lung cancer spheroids reveals advantages of 3D sp Heroids over 2D monolayers, wherein novel therapeutic targets were identified, such as carboxypeptidase D (CPD).
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Optimized protocol for an inducible rat model of liver tumor with chronic hepatocellular injury, inflammation, fibrosis, and cirrhosis.
Zhiao Chen,Shengli Li,Leng Han,Xianghuo He +3 more
- 19 Feb 2021
TL;DR: Chen et al. as discussed by the authors used a rat model to establish liver cancer via chronic administration of diethylnitrosamine, which causes liver tumors with a sequential progression of hepatitis, cirrhosis, and tumor formation.
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