174 Papers
311 Citations
Leng Han is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 50, co-authored 149 publications. Previous affiliations of Leng Han include Kunming Institute of Zoology & University of Texas at Austin.
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Papers
The Mutational and Transcriptional Landscapes of Hepatocarcinogenesis in a Rat Model.
Zhiao Chen,Shengli Li,Shengli Li,Mengting Shen,Xin-Yuan Lu,Chunyang Bao,Di Chen,Jie Ding,Qifeng Wang,Shenglin Huang,Wenming Cong,Leng Han,Xianghuo He +12 more
TL;DR: The dynamic immune response during hepatocarcinogenesis, such as continuous decline of monocytes, suggests an immunological intervention strategy beyond chemoprevention for liver cancer and is identified as a potential biomarker indicating HCC recurrence.
13
Gene- and evidence-based candidate gene selection for schizophrenia and gene feature analysis
TL;DR: The scientific landscape for schizophrenia genetics and other complex disease studies is expected to change dramatically in the next a few years, thus, the gene-based combined OR method is useful in candidate gene selection for follow-up association studies and in further artificial intelligence in medicine.
13
Transforming growth factor β1 alters the 3'-UTR of mRNA to promote lung fibrosis.
Junsuk Ko,Tingting Mills,Jingjing Huang,Ning Yuan Chen,Tinne C.J. Mertens,Scott D. Collum,Garam Lee,Yu Xiang,Leng Han,Yang Zhou,Chun Geun Lee,Jack A. Elias,S. Jyothula,Keshava Rajagopal,Harry Karmouty-Quintana,Michael R. Blackburn +15 more
TL;DR: It is demonstrated here that NUDT21 is depleted by TGFβ1, and the results identified TGF β1 as an APA regulator through N UDT21 depletion amplifying pulmonary fibrosis.
11
Antagonistic actions of two human Pan3 isoforms on global mRNA turnover
TL;DR: It is proposed that the first phase of deadenylation, coordinated through the interplay among the two Pan3 isoforms, Pan2, and PABP, represents a cytoplasmic mRNA maturation step important for proper mRNA turnover.
ZHX2 Promotes HIF1α Oncogenic Signaling in Triple-Negative Breast Cancer
Wentong Fang,Wentong Fang,Chengheng Liao,Rachel Shi,Jeremy M. Simon,Travis S. Ptacek,Giada Zurlo,Youqiong Ye,Youqiong Ye,Leng Han,Cheng Fan,Christopher Llynard Ortiz,Hong-Rui Lin,Ujjawal Manocha,Weibo Luo,William Y. Kim,Lee-Wei Yang,Qing Zhang +17 more
TL;DR: Zhang et al. as mentioned in this paper showed that ZHX2 bound with hypoxia inducible factor (HIF) family members and positively regulated HIF1α activity in TNBC.