174 Papers
311 Citations
Leng Han is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 50, co-authored 149 publications. Previous affiliations of Leng Han include Kunming Institute of Zoology & University of Texas at Austin.
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Papers
Abnormal Calcium Handling Properties Underlie Familial Hypertrophic Cardiomyopathy Pathology in Patient-Specific Induced Pluripotent Stem Cells
Feng Lan,Andrew S. Lee,Ping Liang,Veronica Sanchez-Freire,Patricia K. Nguyen,Li Wang,Leng Han,Michelle Yen,Yongming Wang,Ning Sun,Oscar J. Abilez,Shijun Hu,Antje D. Ebert,Enrique G. Navarrete,Chelsey S. Simmons,Matthew T. Wheeler,Beth L. Pruitt,Richard S. Lewis,Yoshinori Yamaguchi,Euan A. Ashley,Donald M. Bers,Robert C. Robbins,Michael T. Longaker,Joseph C. Wu +23 more
TL;DR: Patients generating patient-specific induced pluripotent stem cell cardiomyocytes from a ten-member family cohort carrying a hereditary HCM missense mutation (Arg663His) in the MYH7 gene are generated to help elucidate the mechanisms underlying HCM development and identify novel therapies for the disease.
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The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer
Aifu Lin,Chunlai Li,Zhen Xing,Qingsong Hu,Ke Liang,Leng Han,Cheng Wang,David H. Hawke,Shouyu Wang,Yanyan Zhang,Yongkun Wei,Guolin Ma,Peter K. Park,Jianwei Zhou,Yan Zhou,Zhibin Hu,Yubin Zhou,Jeffery R. Marks,Han Liang,Mien Chie Hung,Chunru Lin,Liuqing Yang +21 more
TL;DR: A cytoplasmic lncRNA is identified, LINK-A, which mediates HB-EGF-triggered, EGFR:GPNMB heterodimer-dependent HIF1α phosphorylation at Tyr 565 and Ser 797 by BRK and LRRK2, respectively, and correlates with triple-negative breast cancer (TNBC), promoting breast cancer glycolysis reprogramming and tumorigenesis.
The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers.
Leng Han,Lixia Diao,Shuangxing Yu,Xiaoyan Xu,Xiaoyan Xu,Jie Li,Rui Zhang,Yang Yang,Yang Yang,Henrica M.J. Werner,Henrica M.J. Werner,A. Karina Eterovic,Yuan Yuan,Jun Li,Nikitha Nair,Rosalba Minelli,Yiu Huen Tsang,Lydia W.T. Cheung,Kang Jin Jeong,Jason Roszik,Zhenlin Ju,Scott E. Woodman,Yiling Lu,Kenneth L. Scott,Jin Billy Li,Gordon B. Mills,Han Liang +26 more
TL;DR: The effects of several cross-tumor nonsynonymous RNA editing events on cell viability are experimentally demonstrated and the evidence that RNA editing could selectively affect drug sensitivity is provided, highlighting RNA editing as an exciting theme for investigating cancer mechanisms, biomarkers, and treatments.
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TANRIC: An Interactive Open Platform to Explore the Function of lncRNAs in Cancer.
TL;DR: Using recent large-scale RNA-seq datasets, a large number of lncRNAs with potential biomedical significance are identified, many of which show strong correlations with established therapeutic targets and biomarkers across tumor types or with drug sensitivity across cell lines.
Single-cell and spatial analysis reveal interaction of FAP+ fibroblasts and SPP1+ macrophages in colorectal cancer
Jingjing Qi,Hongxiang Sun,Yao Zhang,Zhengting Wang,Zhenzhen Xun,Ziyi Li,X.D. Ding,Rujuan Bao,Liwen Hong,Wen-Qing Jia,Fei Fang,Hongzhi Liu,Lei Chen,Jie Zhong,Duo-Wu Zou,Lianxin Liu,Leng Han,Florent Ginhoux,Yingbin Liu,Youqiong Ye,Bingwei Su +20 more
TL;DR: In this paper , the tumor-specific FAP+ fibroblasts and SPP1+ macrophages were positively correlated in 14 independent CRC cohorts containing 2550 samples and validate their close localization by immuno-fluorescent staining and spatial transcriptomics.