174 Papers
311 Citations
Leng Han is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 50, co-authored 149 publications. Previous affiliations of Leng Han include Kunming Institute of Zoology & University of Texas at Austin.
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Papers
Rewired functional regulatory networks among miRNA isoforms (isomiRs) from let-7 and miR-10 gene families in cancer.
Tingming Liang,Leng Han,Li Guo +2 more
TL;DR: In this paper, the potential evolutionary and functional relationships of multiple isomiRs based on let-7 and miR-10 gene families were revealed, indicating selection of the predominant sequence.
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Identification of a STIM1 Splicing Variant that Promotes Glioblastoma Growth
Jiansheng Xie,Guolin Ma,Lijuan Zhou,Lin He,Zhao Zhang,Peng Tan,Zixian Huang,Shaohai Fang,Tianlu Wang,Yi-Tsang Lee,Shufan Wen,Stefan Siwko,Liuqing Wang,Jindou Liu,Yangchun Du,Ningxia Zhang,Xiaoxuan Liu,Leng Han,Yu Huang,Rui Wang,Youjun Wang,Yubin Zhou,Weidong Han +22 more
TL;DR: A splicing variant‐specific tumor‐promoting role of STIM1β that can be potentially targeted for glioblastoma intervention is established.
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Methylation of promoters of microRNAs and their host genes in myelodysplastic syndromes
Begum Erdogan,Amma Bosompem,Dunfa Peng,Leng Han,Emily A. Smith,Mija E. Kennedy,Catherine E. Alford,Huiyun Wu,Zhongming Zhao,Claudio A. Mosse,Wael El-Rifai,Annette S. Kim +11 more
TL;DR: It is demonstrated that these miRNAs are predominantly intragenic, and that, in many cases, they and their host genes are expressed in a similar pattern during myeloid maturation, suggesting their co-regulation.
Ferroptotic therapy in cancer: benefits, side effects, and risks
Jiandong Diao,Yuanyuan Jia,Enyong Dai,Jiao Liu,Rui Kang,Daolin Tang,Leng Han,Yingjie Zhong,Lingjun Meng +8 more
TL;DR: Ferroptosis, a regulated cell death, shows promise in cancer therapy, complementing chemotherapy, immunotherapy, and radiotherapy, but poses risks of immune cell death, organ damage, cachexia, and secondary tumorigenesis, necessitating mitigation strategies.
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Adverse events associated with potential drugs for COVID-19: a case study from real-world data.
Ying Jing,Lixia Diao,Leng Han +2 more
TL;DR: While these drugs hold promise to fight the global pandemic, healthcare providers should pay attention to AEs to maximize the treatment benefit while minimizing toxicity.
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