174 Papers
311 Citations
Leng Han is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 50, co-authored 149 publications. Previous affiliations of Leng Han include Kunming Institute of Zoology & University of Texas at Austin.
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Papers
Variable Activation of the DNA Damage Response Pathways in Patients Undergoing Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging
Won Hee Lee,Patricia K. Nguyen,Shijun Hu,Grace Liang,Sang-Ging Ong,Leng Han,Veronica Sanchez-Freire,Andrew S. Lee,Minal Vasanawala,George M. Segall,Joseph C. Wu +10 more
TL;DR: Although only a small subset of patients had increased protein phosphorylation and elevated gene expression postimaging, continued care should be taken to reduce radiation exposure to both the patients and operators.
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tRic: a user-friendly data portal to explore the expression landscape of tRNAs in human cancers
TL;DR: Using miRNA-seq data from The Cancer Genome Atlas, quantified the relative expression of tRNA genes and merged them into the codon level and amino level across 31 cancer types and linked alterations of tRNAs expression with protein translational efficiency.
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circRIP: an accurate tool for identifying circRNA-RBP interactions
Xin Dong,Ken Chen,Wenbo Chen,Jun Wang,Liuping Chang,Jin Deng,Lei Wei,Leng Han,ChunHua Huang,Chunjiang He +9 more
TL;DR: An accurate and sensitive tool, circRIP, is provided to systematically identify RBP and circRNA interactions from RIP-Seq and eCLIP data, which can significantly benefit the research community for the functional exploration of circRNAs.
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Functional significance of gain-of-function H19 lncRNA in skeletal muscle differentiation and anti-obesity effects.
Yajuan Li,Yaohua Zhang,Qingsong Hu,Sergey D. Egranov,Zhen Xing,Zhao Zhang,Ke Liang,Youqiong Ye,Yinghong Pan,Sujash S. Chatterjee,Brandon Mistretta,Tina K. Nguyen,David H. Hawke,Preethi H. Gunaratne,Mien Chie Hung,Leng Han,Leng Han,Liuqing Yang,Chunru Lin +18 more
TL;DR: In this article, a gain-of-function (GOF) mutant of H19 was identified and the effects on myoblast differentiation and fusion to myotubes using iPSCs.
GPEdit: the genetic and pharmacogenomic landscape of A-to-I RNA editing in cancers.
Hang Ruan,Qiang Li,Yuan Liu,Yaoming Liu,Charles Lussier,Charles Lussier,Lixia Diao,Leng Han,Leng Han +8 more
TL;DR: GPEdit as discussed by the authors provides a global map of the genetic and pharmacogenomic landscape of RNA editing, which provides an opportunity to better understand the genetic impact and the effects on drug response in cancers.
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