174 Papers
311 Citations
Leng Han is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 50, co-authored 149 publications. Previous affiliations of Leng Han include Kunming Institute of Zoology & University of Texas at Austin.
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Papers
The genetic and pharmacogenomic landscape of snoRNAs in human cancer.
Yaoming Liu,Yaoming Liu,Hang Ruan,Shengli Li,Youqiong Ye,Wei Hong,Jing Gong,Zhao Zhang,Ying Jing,Xiulan Zhang,Lixia Diao,Leng Han +11 more
TL;DR: This study characterized the effects of genetic variants on snoRNAs across 29 cancer types and further linked related alleles with patient survival as well as genome-wide association study risk loci, and characterized the impact of snoRNA expression on drug response in patients to facilitate the clinical utility of snORNAs in cancer.
Suppression of cleavage factor Im 25 promotes the proliferation of lung cancer cells through alternative polyadenylation.
Jingjing Huang,Tingting Weng,Junsuk Ko,Ning Yuan Chen,Yu Xiang,Kelly A. Volcik,Leng Han,Michael R. Blackburn,Xiang Lu +8 more
TL;DR: It is suggested that CFIm25 plays an important role in lung cancer cell proliferation through regulating the APA of oncogenes, including IGF1R, and promoting their protein expression.
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Downregulation of CFIm25 amplifies dermal fibrosis through alternative polyadenylation
Tingting Weng,Jingjing Huang,Jingjing Huang,Eric J. Wagner,Junsuk Ko,Minghua Wu,Nancy Wareing,Yu Xiang,Ning Yuan Chen,Ping Ji,Jose G. Molina,Kelly A. Volcik,Leng Han,Maureen D. Mayes,Michael R. Blackburn,Shervin Assassi +15 more
TL;DR: This study implicates the key regulator of alternative polyadenylation, CFIm25 in dermal fibrosis and in systemic sclerosis (scleroderma) pathogenesis, and downregulation promotes the expression of profibrotic factors, exaggerates bleomycin-induced skin fibrosis, while CFIm 25 restoration attenuates skin Fibrosis.
THO Complex-Dependent Posttranscriptional Control Contributes to Vascular Smooth Muscle Cell Fate Decision.
Xinli Yuan,Tao Zhang,Fang Yao,Yingnan Liao,Fei Liu,Zongna Ren,Leng Han,Lixia Diao,Yankui Li,Bingying Zhou,Fan He,Li Wang +11 more
TL;DR: In this article, the role of vascular smooth muscle cells (VSMC) phenotype plays a fundamental role in vascular development and diseases, although extensive studies uncovered the roles of transcriptiona...
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Comprehensive Molecular Characterization of Mitochondrial Genomes in Human Cancers
Yuan Yuan,Young Seok Ju,Young-Wook Kim,Jun Li,Yumeng Wang,Yang Yang,Inigo Martincorena,Chad J. Creighton,John N. Weinstein,Yanxun Xu,Leng Han,Hyung Lae Kim,Hidewaki Nakagawa,Keunchil Park,Peter J. Campbell,Han Liang +15 more
TL;DR: This analysis presents the most definitive mutational landscape of mitochondrial genomes including a novel hypermutated case and observes similar mutational signatures across cancer types, suggesting powerful endogenous mutational processes in mitochondria.