174 Papers
311 Citations
Leng Han is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 50, co-authored 149 publications. Previous affiliations of Leng Han include Kunming Institute of Zoology & University of Texas at Austin.
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Papers
Systematic Prioritization and Integrative Analysis of Copy Number Variations in Schizophrenia Reveal Key Schizophrenia Susceptibility Genes
Xiong-Jian Luo,Xiong-Jian Luo,Xiong-Jian Luo,Liang Huang,Leng Han,Zhenwu Luo,Fang Hu,Roger Tieu,Lin Gan,Lin Gan +9 more
TL;DR: The identified key candidate genes may have important roles in the pathogenesis of schizophrenia, and further functional characterization of these genes may provide pivotal targets for future therapeutics and diagnostics.
Targeting Glucose Metabolism Sensitizes Pancreatic Cancer to MEK Inhibition
Liang Yan,Bo Tu,Jun Yao,Jing Gong,Alessandro Carugo,Christopher A. Bristow,Qiuyun Wang,Cihui Zhu,Bingbing Dai,Ya'an Kang,Leng Han,Ningping Feng,Yanqing Jin,Jason B. Fleming,Timothy P. Heffernan,Wantong Yao,Haoqiang Ying +16 more
TL;DR: This article investigated the requirement of these pathways for tumor maintenance using an inducible KrasG12D-driven PDAC mouse model (iKras model), identifying that RAF-MEK-MAPK signaling is the major effector for oncogenic KRAS-mediated tumor maintenance.
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Cell Transplantation and Tissue Regeneration Safe Genetic Modification of Cardiac Stem Cells Using a Site-Specific Integration Technique
Feng Lan,Junwei Liu,Kazim H. Narsinh,Shijun Hu,Leng Han,Andrew S. Lee,Marisa Karow,Patricia K. Nguyen,Divya Nag,Michele P. Calos,Robert C. Robbins,Joseph C. Wu +11 more
- 01 Jan 2012
TL;DR: Lan et al. as mentioned in this paper proposed a technique for safe genetic modification of Cardiac Stem Cells using a Site-Specific Integration (SSEI) integration tool, which can be found in the Appendix of this paper.
Discovery of Small-Molecule Inhibitors of the HSP90-Calcineurin-NFAT Pathway against Glioblastoma.
Zhenzhen Liu,Hongli Li,Lian He,Yu Xiang,Chengsen Tian,Can Li,Peng Tan,Ji Jing,Yanpin Tian,Lupei Du,Yun Huang,Leng Han,Minyong Li,Yubin Zhou +13 more
TL;DR: The discovery of a class of inhibitors (YZ129 and its derivatives) of the calcineurin-NFAT pathway that exhibited potent anti-tumor activity against GBM is reported, highlighting the potential for targeting the cancer-promoting HSP90 chaperone network to treat GBM.
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Contrast features of CpG islands in the promoter and other regions in the dog genome
Leng Han,Zhongming Zhao +1 more
TL;DR: Analysis of functional features of dog-human-mouse homologous genes suggests that the dog might have undergone a faster erosion rate of promoter-associated CGIs than the human or mouse.
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