174 Papers
311 Citations
Leng Han is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 50, co-authored 149 publications. Previous affiliations of Leng Han include Kunming Institute of Zoology & University of Texas at Austin.
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Papers
The Beneficial Role of Sunitinib in Tumor Immune Surveillance by Regulating Tumor PD-L1.
Hui Li,Hui Li,Xinwei Kuang,Long Liang,Youqiong Ye,Youqiong Ye,Yongchang Zhang,Jialu Li,Fangyu Ma,Juan Tao,Guang Lei,Shuang Zhao,Juan Su,Nong Yang,Cong Peng,Xiaowei Xu,Mien Chie Hung,Leng Han,Hong Liu,Jing Liu,Xiang Chen +20 more
TL;DR: A novel molecular mechanism is revealed regarding the regulation of PD‐L1 via p62, thus providing a novel therapeutic strategy by the combination treatment of CTLA‐4 with Sunitinib.
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Escherichia coli Metabolite Profiling Leads to the Development of an RNA Interference Strain for Caenorhabditis elegans.
Isaiah A.A. Neve,Jessica N. Sowa,Chih-Chun J Lin,Priya Sivaramakrishnan,Christophe Herman,Youqiong Ye,Leng Han,Meng C. Wang,Meng C. Wang +8 more
TL;DR: The importance of specific bacterial metabolites in regulating the host’s physiology is suggested and an RNA interference competent OP50 (iOP50) strain is generated to prevent confounding effects when analyzing genotype-phenotype interactions under different bacterial backgrounds.
Correction to Allele-Specific Reprogramming of Cancer Metabolism by the Long Non-coding RNA CCAT2 [Molecular Cell 61, 520-534, (2016)]
Roxana S. Redis,Luz E. Vela,Weiqin Lu,Juliana Ferreira de Oliveira,Cristina Ivan,Cristian Rodriguez-Aguayo,Douglas Adamoski,Barbara Pasculli,Ayumu Taguchi,Yunyun Chen,Agustín F. Fernández,Luis Valledor,Katrien Van Roosbroeck,Samuel Chang,Maitri Y. Shah,Garrett Kinnebrew,Leng Han,Yaser Atlasi,Lawrence H. Cheung,Gilbert Yuanjay Huang,Paloma Monroig,Marc S. Ramirez,Tina Catela Ivkovic,Long Van,Hui Ling,Roberta Gafà,Sanja Kapitanović,Giovanni Lanza,James A. Bankson,Peng Huang,Stephen Y. Lai,Robert C. Bast,Michael G. Rosenblum,Milan Radovich,Mircea Ivan,Geoffrey Bartholomeusz,Han Liang,Mario F. Fraga,William R. Widger,Samir M. Hanash,Ioana Berindan-Neagoe,Gabriel Lopez-Berestein,Andre Luis Berteli Ambrosio,Sandra Martha Gomes Dias,George A. Calin +44 more
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HeRA: an atlas of enhancer RNAs across human tissues.
Zhao Zhang,Wei Hong,Hang Ruan,Ying Jing,Shengli Li,Yaoming Liu,Jun Wang,Wenbo Li,Lixia Diao,Leng Han +9 more
TL;DR: HeRA is the first data portal to characterize eRNAs from 9577 samples across 54 human tissues and facilitates functional and mechanistic investigations of eRN as well as a co-expression network to identify millions of putative eRNA regulators and target genes across different tissues.
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Integrated genomic analysis of recurrence-associated small non-coding RNAs in oesophageal cancer
Hee Jin Jang,Hyun-Sung Lee,Bryan M. Burt,Geon Kook Lee,Kyong Ah Yoon,Yun Yong Park,Bo Hwa Sohn,Sang Bae Kim,Moon Soo Kim,Jong Mog Lee,Jungnam Joo,Sang Cheol Kim,Ju Sik Yun,Kook Joo Na,Yoon-La Choi,Jong Lyul Park,Seon-Young Kim,Yong Sun Lee,Leng Han,Han Liang,Duncan Mak,Jared K. Burks,Jae Ill Zo,David J. Sugarbaker,Young Mog Shim,Ju Seog Lee +25 more
TL;DR: An easy-to-use prognostic model with three sncRNAs as robust prognostic markers for postoperative recurrence of ESCC is developed and it is anticipated that such a stratified and systematic, tumour-specific biological approach will potentially contribute to significant improvement in ESCC treatment.