174 Papers
311 Citations
Leng Han is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 50, co-authored 149 publications. Previous affiliations of Leng Han include Kunming Institute of Zoology & University of Texas at Austin.
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Papers
A Multi-Omics Perspective of Quantitative Trait Loci in Precision Medicine.
TL;DR: Multiple categories of molQTLs are reviewed, including those associated with transcriptome, post-transcriptional regulation, epigenetics, proteomics, metabolomics, and the microbiome, to highlight future opportunities to better understand the functional significance of genetic variants and to utilize the discovery of mol QTLs in precision medicine.
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Transcribed ultraconserved region 339 promotes carcinogenesis by modulating tumor suppressor microRNAs.
Ivan Vannini,Petra Wise,Kishore B. Challagundla,Meropi Plousiou,Mirco Raffini,Erika Bandini,Francesca Fanini,Giorgia Paliaga,Melissa Crawford,Manuela Ferracin,Cristina Ivan,Linda Fabris,Ramana V. Davuluri,Zhiyi Guo,Maria Angelica Cortez,Xinna Zhang,Lu Chen,Shuxing Zhang,Cecilia Fernandez-Cymering,Leng Han,Silvia Carloni,Samanta Salvi,Hui Ling,Mariam Murtadha,Paolo Neviani,Barbara J. Gitlitz,Ite A. Laird-Offringa,Patrick Nana-Sinkam,Massimo Negrini,Han Liang,Dino Amadori,Amelia Cimmino,George A. Calin,Muller Fabbri +33 more
TL;DR: Uc.339 is identified as an oncogene in lung cancer that is upregulated through the loss of TP53 and promotes Cyclin E activation by entrapping regulatory miRNAs.
Ultraconserved long non-coding RNA uc.63 in breast cancer
Alberto Marini,Anna Maria Lena,Emanuele Panatta,Cristina Ivan,Leng Han,Han Liang,Margherita Annicchiarico-Petruzzelli,Nicola Di Daniele,George A. Calin,Eleonora Candi,Gerry Melino,Gerry Melino +11 more
TL;DR: This work found that overexpression of one specific T-UCRs named uc.63 is associated with bad outcome in luminal A subtype of breast cancer patients and offers the prospect to identify a signature associated with poor prognosis.
Reconstruction of the tumor spatial microenvironment along the malignant-boundary-nonmalignant axis
Leng Han,Youqiong Ye +1 more
TL;DR: Cottrazm as discussed by the authors integrates spatial transcriptomics (ST) with hematoxylin and eosin histological image and single-cell transcriptomics to delineate the tumor boundary connecting malignant and non-malignant cell spots in tumor tissues, deconvolute cell-type composition at spatial location, and reconstruct cell type-specific gene expression profiles at sub-spot level.
APAatlas: decoding alternative polyadenylation across human tissues.
Wei Hong,Hang Ruan,Zhao Zhang,Youqiong Ye,Yaoming Liu,Shengli Li,Ying Jing,H. Zhang,Lixia Diao,Han Liang,Leng Han +10 more
TL;DR: This work systematically identified APA events from 9475 samples across 53 human tissues and examined their associations with multiple traits and gene expression across tissues, and developed APAatlas, a user-friendly database for searching, browsing and downloading related information.
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