174 Papers
311 Citations
Leng Han is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 50, co-authored 149 publications. Previous affiliations of Leng Han include Kunming Institute of Zoology & University of Texas at Austin.
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Papers
Comparative Analysis of CpG Islands in Four Fish Genomes
Leng Han,Zhongming Zhao +1 more
TL;DR: It is found that both the number of CGIs and the CGI density vary greatly among these genomes, and each fish genome presents a distinct distribution of CGI density with some genomic factors (e.g., chromosome size and chromosome GC content).
Pancan-meQTL: a database to systematically evaluate the effects of genetic variants on methylation in human cancer.
Jing Gong,Hao Wan,Shufang Mei,Hang Ruan,Zhao Zhang,Chun-Jie Liu,An-Yuan Guo,Lixia Diao,Xiaoping Miao,Leng Han +9 more
TL;DR: Pancan-meQTL is a database to comprehensively provide meQTLs across 23 cancer types from The Cancer Genome Atlas by integrating genome-wide genotype and DNA methylation data and is a valuable resource for investigating the roles of genetics and epigenetics in cancer.
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A noncoding RNA modulator potentiates phenylalanine metabolism in mice.
Yajuan Li,Zhi Tan,Yaohua Zhang,Zhao Zhang,Qingsong Hu,Ke Liang,Yao Jun,Youqiong Ye,Yi Chuan Li,Chunlai Li,Lan Liao,Jianming Xu,Zhen Xing,Yinghong Pan,Sujash S. Chatterjee,Tina K. Nguyen,Heidi Hsiao,Sergey D. Egranov,Nagireddy Putluri,Cristian Coarfa,David H. Hawke,Preethi H. Gunaratne,Kuang-Lei Tsai,Leng Han,Mien Chie Hung,Mien Chie Hung,George A. Calin,Farès Namour,Jean-Louis Guéant,Ania C. Muntau,Nenad Blau,V. Reid Sutton,Manuel Schiff,Manuel Schiff,François Feillet,Shuxing Zhang,Chunru Lin,Liuqing Yang +37 more
TL;DR: The functional role of long noncoding RNAs (lncRNAs) in inherited metabolic disorders, including phenylketonuria (PKU), is unknown.
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CSCD2: an integrated interactional database of cancer-specific circular RNAs.
Jing Feng,Wenbo Chen,Xin Dong,Jun Wang,Xiangfei Mei,Jin Deng,Siqi Yang,Chenjian Zhuo,Xiaoyu Huang,Lin Shao,Rongyu Zhang,Jing Guo,Ronghui Ma,Juan Liu,Feng Li,Ying Wu,Leng Han,Chunjiang He,Chunjiang He +18 more
TL;DR: The Cancer Specific CircRNA Database (CSCD2) as mentioned in this paper is a comprehensive database for cancer-specific circRNAs, which contains >1000 samples (825 tissues and 288 cell lines).
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LncRNAs-directed PTEN enzymatic switch governs epithelial–mesenchymal transition
Qingsong Hu,Chunlai Li,Shouyu Wang,Shouyu Wang,Yajuan Li,Bo Wen,Yanyan Zhang,Yanyan Zhang,Ke Liang,Jun Yao,Youqiong Ye,Heidi Hsiao,Tina K. Nguyen,Peter K. Park,Sergey D. Egranov,David H. Hawke,Jeffrey R. Marks,Leng Han,Mien Chie Hung,Bing Zhang,Chunru Lin,Liuqing Yang +21 more
TL;DR: It is reported that K27-linked polyubiquitination of PTEN at lysines 66 and 80 switches its phosphoinositide/protein tyrosine phosphatase activity to protein serine/threonine phosph atase activity, illustrating an unexpected paradigm in which the lncRNA-dependent switch in PTEN protein Serine/Threonine phosphate activity is important for physiological homeostasis and disease development.
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