174 Papers
311 Citations
Leng Han is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 50, co-authored 149 publications. Previous affiliations of Leng Han include Kunming Institute of Zoology & University of Texas at Austin.
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Papers
Circular RNAs as promising biomarkers in cancer: detection, function, and beyond.
Shengli Li,Leng Han +1 more
TL;DR: Advances in computational and experimental approaches have allowed advanced characterization of circRNAs, leading the research field into a new era and shedding light on the contribution of circ RNAs to disease.
Cleavage factor 25 deregulation contributes to pulmonary fibrosis through alternative polyadenylation
Tingting Weng,Junsuk Ko,Chioniso P. Masamha,Zheng Xia,Yu Xiang,Ning Yuan Chen,Jose G. Molina,Scott D. Collum,Tinne C.J. Mertens,Fayong Luo,Kemly Philip,Jonathan Davies,Jingjing Huang,Cory Wilson,Rajarajan Amirthalingam Thandavarayan,Brian A. Bruckner,S. Jyothula,Kelly A. Volcik,Lei Li,Leng Han,Wei Li,Shervin Assassi,Harry Karmouty-Quintana,Eric J. Wagner,Michael R. Blackburn +24 more
TL;DR: It is demonstrated that CFIm25, a global regulator of APA, is down-regulated in the lungs of patients with IPF and mice with pulmonary fibrosis, with its expression selectively reduced in alpha-smooth muscle actin positive fibroblasts.
Characterization of the dual functional effects of heat shock proteins (HSPs) in cancer hallmarks to aid development of HSP inhibitors.
Zhao Zhang,Ji Jing,Youqiong Ye,Zhiao Chen,Ying Jing,Shengli Li,Wei Hong,Hang Ruan,Yaoming Liu,Qingsong Hu,Jun Wang,Wenbo Li,Chunru Lin,Lixia Diao,Yubin Zhou,Leng Han +15 more
TL;DR: This study comprehensively analyzed the HSP expression landscape across multiple human cancers and revealed a global disruption of the co-expression network for HSPs, and experimentally characterized the dual function of two genes, DNAJC9 and HSPA14, in lung cancer cells.
Efficient gene delivery of primary human cells using peptide linked polyethylenimine polymer hybrid
Devaveena Dey,Mohammed Inayathullah,Andrew S. Lee,Melburne C. Lemieux,Xuexiang Zhang,Yi Wu,Divya Nag,Patrícia de Almeida,Leng Han,Jayakumar Rajadas,Joseph C. Wu +10 more
TL;DR: Study of the underlying mechanism of the observed phenomena revealed lower levels of 'reactive oxygen species' (ROS) in the presence of the peptide-polymers when compared to PEI alone, which was further corroborated with global gene expression analysis.
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Structural and Functional Insight of Sphingosine 1-Phosphate-Mediated Pathogenic Metabolic Reprogramming in Sickle Cell Disease.
Kaiqi Sun,Angelo D'Alessandro,Mostafa H. Ahmed,Yujin Zhang,Anren Song,Tzu Ping Ko,Travis Nemkov,Julie A. Reisz,Hongyu Wu,Morayo G. Adebiyi,Zhangzhe Peng,Zhangzhe Peng,Jing Gong,Hong Liu,Aji Huang,Yuan Edward Wen,Alexander Q. Wen,Vladimir Berka,Vladimir Berka,Mikhail Bogdanov,Osheiza Abdulmalik,Leng Han,Ah-Lim Tsai,Modupe Idowu,Harinder S. Juneja,Rodney E. Kellems,William Dowhan,Kirk C. Hansen,Martin K. Safo,Yang Xia,Yang Xia +30 more
TL;DR: The findings provide functional and structural bases underlying S1P-mediated pathogenic metabolic reprogramming in SCD and novel therapeutic avenues.