174 Papers
311 Citations
Leng Han is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 50, co-authored 149 publications. Previous affiliations of Leng Han include Kunming Institute of Zoology & University of Texas at Austin.
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Papers
Early stem cell engraftment predicts late cardiac functional recovery: preclinical insights from molecular imaging.
Junwei Liu,Junwei Liu,Kazim H. Narsinh,Feng Lan,Li Wang,Patricia K. Nguyen,Shijun Hu,Andrew S. Lee,Leng Han,Yongquan Gong,Mei Huang,Divya Nag,Jarrett Rosenberg,Alexandra Chouldechova,Robert C. Robbins,Joseph C. Wu +15 more
TL;DR: In this paper, the use of positron emission tomography (PET) gene imaging was evaluated for monitoring human cardiac progenitor cell transplantation in a mouse model of myocardial infarction.
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CancerSplicingQTL: a database for genome-wide identification of splicing QTLs in human cancer.
Jianbo Tian,Zhihua Wang,Shufang Mei,Nan Yang,Yang Yang,Juntao Ke,Ying Zhu,Yajie Gong,Danyi Zou,Xiating Peng,Xiaoyang Wang,Hao Wan,Rong Zhong,Jiang Chang,Jing Gong,Jing Gong,Leng Han,Xiaoping Miao +17 more
TL;DR: A computational pipeline to identify splicing quantitative trait loci (sQTLs), genetic variants that affect AS events, and a user-friendly database, CancerSplicingQTL, which provides an informative sQTL resource for further characterizing the potential functional roles of SNPs that control transcript isoforms in human cancer.
The lncRNA H19 alleviates muscular dystrophy by stabilizing dystrophin.
Yaohua Zhang,Yajuan Li,Qingsong Hu,Yutao Xi,Zhen Xing,Zhao Zhang,Lisa Huang,Jianbo Wu,Ke Liang,Tina K. Nguyen,Sergey D. Egranov,Cheng-Cao Sun,Zilong Zhao,David H. Hawke,Jin Li,Deqiang Sun,Jean J. Kim,Ping Zhang,Jie Cheng,Abid Farida,Mien Chie Hung,Leng Han,Radbod Darabi,Chunru Lin,Liuqing Yang +24 more
TL;DR: This study reports that a long noncoding RNA, H19, associates with dystrophin and inhibits E3 ligase-dependent poly-ubiquitination at Lys3584 and its subsequent protein degradation, paving the way to meaningful targeted therapeutics for BMD and certain DMD patients.
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Expression of Long Noncoding RNA YIYA Promotes Glycolysis in Breast Cancer.
Zhen Xing,Yanyan Zhang,Ke Liang,Liang Yan,Yu Xiang,Chunlai Li,Qingsong Hu,Feng Jin,Vasanta Putluri,Nagireddy Putluri,Cristian Coarfa,Arun Sreekumar,Peter K. Park,Tina Kim Nguyen,Shouyu Wang,Shouyu Wang,Jianwei Zhou,Yan Zhou,Jeffrey R. Marks,David H. Hawke,Mien Chie Hung,Mien Chie Hung,Liuqing Yang,Leng Han,Haoqiang Ying,Chunru Lin +25 more
TL;DR: It is reported that upregulation of the lncRNA LINC00538 (YIYA) promotes glycolysis, cell proliferation, and tumor growth in breast cancer.
RNA m6A modification orchestrates a LINE-1-host interaction that facilitates retrotransposition and contributes to long gene vulnerability.
Feng Xiong,Ruoyu Wang,Ruoyu Wang,Joo-Hyung Lee,Shenglan Li,Shin-Fu Chen,Zian Liao,Zian Liao,Lana Al Hasani,Lana Al Hasani,Phuoc T. Nguyen,Phuoc T. Nguyen,Xiaoyu Zhu,Joanna Krakowiak,Dung Fang Lee,Leng Han,Kuang-Lei Tsai,Kuang-Lei Tsai,Ying Liu,Ying Liu,Wenbo Li,Wenbo Li +21 more
TL;DR: In this article, N6-methyladenosine (m6A) deposition on nascent RNAs in human cells was profiled by developing a new method MINT-Seq, which revealed that many classes of RTE RNAs, particularly intronic LINE-1s, are strongly methylated.