174 Papers
311 Citations
Leng Han is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 50, co-authored 149 publications. Previous affiliations of Leng Han include Kunming Institute of Zoology & University of Texas at Austin.
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Papers
The THO complex regulates pluripotency gene mRNA export and controls embryonic stem cell self-renewal and somatic cell reprogramming.
Li Wang,Yi-Liang Miao,Xiaofeng Zheng,Brad Lackford,Bingying Zhou,Leng Han,Chengguo Yao,James M. Ward,Adam B. Burkholder,Inna Lipchina,David C. Fargo,Konrad Hochedlinger,Yongsheng Shi,Carmen J. Williams,Guang Hu +14 more
TL;DR: It is shown that THO preferentially interacts with pluripotency gene transcripts through Thoc5 and is required for self-renewal at least in part by regulating their export and expression, and therefore a role for this aspect of posttranscriptional regulation in stem cell fate specification is uncovered.
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INO80 governs superenhancer-mediated oncogenic transcription and tumor growth in melanoma
Bingying Zhou,Li Wang,Shu Zhang,Brian D. Bennett,Fan He,Yan Zhang,Chengliang Xiong,Leng Han,Lixia Diao,Pishun Li,David C. Fargo,Adrienne D. Cox,Guang Hu +12 more
TL;DR: It is shown that INO80, a chromatin remodeling complex, is required for SE-mediated oncogenic transcription and tumor growth in melanoma and a novel strategy for disrupting SEs in cancer treatment is suggested.
TRIM59 promotes breast cancer motility by suppressing p62-selective autophagic degradation of PDCD10
Peng Tan,Peng Tan,Youqiong Ye,Lian He,Jiansheng Xie,Ji Jing,Guolin Ma,Hongming Pan,Leng Han,Weidong Han,Yubin Zhou +10 more
TL;DR: It is reported that tripartite motif (TRIM) 59 is frequently up-regulated in metastatic breast cancer, which is correlated with advanced clinical stages and reduced survival among breast cancer patients, establishing the rationale for targeting deregulated TRIM59/PDCD10 to treat breast cancer.
Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent
Anren Song,Yujin Zhang,Leng Han,Gennady G. Yegutkin,Hong Liu,Kaiqi Sun,Angelo D'Alessandro,Jessica Li,Harry Karmouty-Quintana,Takayuki Iriyama,Takayuki Iriyama,Tingting Weng,Shushan Zhao,Shushan Zhao,Wei Wang,Wei Wang,Hongyu Wu,Travis Nemkov,Andrew W. Subudhi,Sonja Jameson-Van Houten,Colleen G. Julian,Andrew T. Lovering,Kirk C. Hansen,Hong Zhang,Mikhail Bogdanov,William Dowhan,Jianping Jin,Rodney E. Kellems,Holger K. Eltzschig,Michael R. Blackburn,Robert C. Roach,Yang Xia,Yang Xia +32 more
TL;DR: It is reported that in healthy lowlanders, plasma adenosine levels are rapidly induced by initial ascent to high altitude and achieved even higher levels upon re-ascent, a feature that is positively associated with quicker acclimatization.
Conservation and divergence of DNA methylation in eukaryotes: New insights from single base-resolution DNA methylomes
Zhixi Su,Leng Han,Zhongming Zhao +2 more
TL;DR: This work aims to summarize the current state of available methylome data and features informatively and systematically review the features of whole genome DNA methylation patterns in eight animals, six plants and five fungi to provide new insights into the conservation and divergence in eukaryotes.