Leila K. Needham
Duke University
4 Papers
132 Citations
Leila K. Needham is an academic researcher from Duke University. The author has contributed to research in topics: Microglia & Apolipoprotein E. The author has an hindex of 4, co-authored 4 publications. Previous affiliations of Leila K. Needham include Durham University.
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Papers
APOE and the regulation of microglial nitric oxide production: a link between genetic risk and oxidative stress
Carol A. Colton,Candice M. Brown,Danielle Cook,Leila K. Needham,Qing Xu,Meggan Czapiga,Ann M. Saunders,Donald E. Schmechel,Karima Rasheed,Michael P. Vitek +9 more
TL;DR: Greater NO production in APOE4 carriers where characteristically high levels of oxidative/nitrosative stress are found in diseases such as AD provides a mechanism that potentially explains the genetic association between APoe4 and human diseases.
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APOE genotype-specific differences in human and mouse macrophage nitric oxide production.
Carol A. Colton,Leila K. Needham,Candice M. Brown,Danielle Cook,Karima Rasheed,James R. Burke,Warren J. Strittmatter,Donald E. Schmechel,Michael P. Vitek +8 more
TL;DR: The enhanced macrophage responsiveness and the increased production of NO in APOE4 AD patients may predispose the CNS to an increased potential for nitration and nitrosation, consistent with the redox imbalance and neuroinflammatory state seen in AD.
81
Evaluation and recommendations on good clinical laboratory practice guidelines for phase I-III clinical trials.
Marcella Sarzotti-Kelsoe,Josephine H. Cox,Naana Cleland,Thomas N. Denny,John Hural,Leila K. Needham,Leila K. Needham,Daniel A. Ozaki,Isaac R. Rodriguez-Chavez,Gwynneth Stevens,Timothy A. Stiles,Tony Tarragona-Fiol,Anita H. Simkins +12 more
TL;DR: Marcella Sarzotti-Kelsoe and colleagues harmonize various approaches to Good Clinical Laboratory Practice for clinical trials into a single set of recommendations.
The Center for HIV/AIDS Vaccine Immunology (CHAVI) multi-site quality assurance program for cryopreserved human peripheral blood mononuclear cells.
Marcella Sarzotti-Kelsoe,Leila K. Needham,Wes Rountree,John Bainbridge,Clive M. Gray,Susan A. Fiscus,Guido Ferrari,Wendy S. Stevens,Susan L. Stager,Whitney Binz,Raul Louzao,Kristy O. Long,Pauline Mokgotho,Niranjini Moodley,Melanie Mackay,Melissa Kerkau,Takesha McMillion,Jennifer L. Kirchherr,Kelly A. Soderberg,Barton F. Haynes,Thomas N. Denny +20 more
TL;DR: A three-stage program was designed, based on Good Clinical Laboratory Practices (GCLP), to monitor PBMC integrity at each step of this process, highlighting the relative importance of each of these stages to the ultimate goal of preserving specimen integrity from peripheral blood collection to long-term repository storage.