Leila Dorling
University of Cambridge
33 Papers
26 Citations
Leila Dorling is an academic researcher from University of Cambridge. The author has contributed to research in topics: Breast cancer & Medicine. The author has an hindex of 14, co-authored 20 publications.
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Papers
Hereditary breast and ovarian cancer: successful systematic implementation of a group approach to genetic counselling
Patrick R. Benusiglio,Marina Di Maria,Leila Dorling,Anne Jouinot,Anne Jouinot,Antoine Poli,Sophie Villebasse,Marine Le Mentec,Béatrice Claret,Diane Boinon,Olivier Caron +10 more
TL;DR: Thanks to group counselling, patients with suspected Hereditary Breast and Ovarian Cancer have withstood increases in referrals without compromising care, and this innovative approach should ensure that all patients have access to approved services.
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Common genetic variation associated with increased susceptibility to prostate cancer does not increase risk of radiotherapy toxicity
Mahbubl Ahmed,Leila Dorling,Sarah L. Kerns,Laura Fachal,Rebecca Elliott,Matt Partliament,Barry S. Rosenstein,Ana Vega,Antonio Gómez-Caamaño,Gill Barnett,David P. Dearnaley,Emma Hall,Matthew R. Sydes,Neil G. Burnet,Paul D.P. Pharoah,Ros Eeles,Catharine M L West +16 more
TL;DR: Patients with a high polygenic susceptibility for prostate cancer have no increased risk for developing late radiotherapy toxicity, suggesting that patients with a genetic predisposition for prostate cancers, inferred by common variants, can be safely treated using current standard radiotherapy regimens.
The relationship between common genetic markers of breast cancer risk and chemotherapy-induced toxicity: A case-control study
Leila Dorling,Siddhartha Kar,Kyriaki Michailidou,Kyriaki Michailidou,Louise Hiller,Anne-Laure Vallier,Susan Ingle,Richard R. Hardy,Sarah Bowden,Janet A. Dunn,Chris Twelves,Christopher J. Poole,Carlos Caldas,Helena M. Earl,Paul D.P. Pharoah,Jean Abraham +15 more
TL;DR: It is suggested that breast cancer patients with high genetic risk of breast cancer, conferred by common variants, can safely receive standard chemotherapy without increased risk of taxane-related sensory neuropathy or chemotherapy-induced neutropenia and may experience less neutropania.
Meta-GWAS identifies the heritability of acute radiation-induced toxicities in head and neck cancer.
Elnaz Naderi,L.M. Schack,Ceilidh Welsh,Adelene Y.L. Sim,Miguel E. Aguado-Barrera,Tom Dudding,Holly Summersgil,Laura Martinez-Calvo,Enya H.W. Ong,Y. Odding,Ana Varela-Pazos,Roel J H M Steenbakkers,Anne P G Crijns,Raj Jena,Miranda Pring,Joe Dennis,Ramón Lobato-Busto,Jan Alsner,Andy R Ness,Christopher M. Nutting,David J Thomson,Antonio Gómez-Caamaño,Jesper Grau Eriksen,Steven R. Thomas,A. Bates,Jens Overgaard,Luis M. Cascallar-Caneda,Fréderic Duprez,Gillian C. Barnett,Leila Dorling,Melvin L. K. Chua,Ana Vega,Catharine M L West,Johannes A. Langendijk,Christian Nicolaj Andreassen,Behrooz Z. Alizadeh +35 more
TL;DR: In this paper , the authors aimed to the genetic components and susceptibility variants associated with acute radiation-induced toxicities (RITs) in patients with head and neck cancer (HNC).
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Large-Scale Meta-GWAS Reveals Common Genetic Factors Linked to Radiation-Induced Acute Toxicities across Cancers.
Elnaz Naderi,Miguel E. Aguado-Barrera,L.M. Schack,Leila Dorling,T. Rattay,Laura Fachal,Holly R. Summersgill,Laura Martinez-Calvo,Ceilidh Welsh,Tom Dudding,Y. Odding,Ana Varela-Pazos,Rajesh Jena,David J Thomson,Roel J H M Steenbakkers,Joe Dennis,Ramón Lobato-Busto,Jan Alsner,Andy Ness,C. Nutting,Antonio Gómez-Caamaño,J Grau Eriksen,Steve J Thomas,A. Bates,A. Webb,Ananya Choudhury,B. S. Rosenstein,Begoña Taboada-Valladares,Carsten Herskind,D. Azria,D. P. Dearnaley,Dirk de Ruysscher,Elena Sperk,Emma Hall,Hilary Stobart,J. Chang-Claude,Kim De Ruyck,Liv Veldeman,Manolo Altabas,M. De Santis,Marie-Pierre Farcy-Jacquet,Marlon R. Veldwijk,Matthew R. Sydes,Matthew Parliament,Nawaid Usmani,Neil G. Burnet,Petra Seibold,R. Paul Symonds,Rebecca Elliott,Renée Bultijnck,Sara Gutiérrez-Enríquez,Meritxell Mollà,Sarah L. Gulliford,Sheryl Green,Tiziana Rancati,Victoria Reyes,Ana Carballo,Paula Peleteiro,Paloma Sosa-Fajardo,Chris Parker,Valérie Fonteyne,Kerstie Anne Johnson,Maarten Lambrecht,B. Vanneste,Riccardo Valdagni,A. Giraldo,Mónica Ramos,Brenda Diergaarde,Geoffrey Liu,Suzanne M Leal,Melvin L.K. Chua,Miranda Pring,J. Overgaard,Luis M. Cascallar-Caneda,Fréderic Duprez,C. Talbot,Gillian C. Barnett,Alison M. Dunning,Ana Vega,Christian Nicolaj Andreassen,Johannes A. Langendijk,Catharine M L West,Behrooz Z. Alizadeh,Sarah L. Kerns +83 more
TL;DR: There is shared SNV-based heritability for acute radiation-induced toxicity across and within individual cancer sites, and rs142667902 showed the strongest association.
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