Lei Yang
Sichuan University
7 Papers
96 Citations
Lei Yang is an academic researcher from Sichuan University. The author has contributed to research in topics: One-pot synthesis & Indole test. The author has an hindex of 4, co-authored 7 publications.
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Papers
Elements of regiocontrol in the direct heteroarylation of indoles/pyrroles: synthesis of bi- and fused polycyclic heteroarenes by twofold or tandem fourfold C-H activation.
Zhen Wang,Feijie Song,Yinsong Zhao,Yumin Huang,Lei Yang,Dongbing Zhao,Jingbo Lan,Jingsong You +7 more
TL;DR: Cross-coupling: the "chelation-directed control" and "catalytic-system-based control" strategies effectively switch the C2/C3-site selectivity in the heteroarylation of indoles and pyrroles with N-heteroarenes by a palladium-catalyzed twofold C-H activation to form biheteroarednes.
81
Organocatalytic Asymmetric Synthesis of Spiro-oxindole Piperidine Derivatives That Reduce Cancer Cell Proliferation by Inhibiting MDM2–p53 Interaction
Ming-Cheng Yang,Ming-Cheng Yang,Cheng Peng,Hua Huang,Lei Yang,Xiang-Hong He,Wei Huang,Hai-Lei Cui,Gu He,Bo Han +9 more
TL;DR: Mechanistic studies suggest that the most potent compound 9e can directly interfere with MDM2-p53 interactions and elevate protein levels of p53 and p21, thereby inducing cell cycle arrest and mitochondrial apoptosis.
81
Silver-catalyzed one-pot cyclization/fluorination of 2-alkynylanilines: highly efficient synthesis of structurally diverse fluorinated indole derivatives
TL;DR: Highly efficient approaches to obtain structurally diverse fluorinated indole derivatives have been realized through the Ag-catalyzed one-pot cyclization/fluorination of 2-alkynylanilines in the presence of NFSI or Selectfluor.
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One-pot synthesis of diarylimidazolium salts from 1H-imidazole
TL;DR: In this paper, the diarylimidazolium salts were directly synthesized starting from 1 H -imidazole by a one-pot strategy using diaryliodonium salts as the arylating reagents.
18
One‐Pot Synthesis of Diarylimidazolium Salts from 1H‐Imidazole.
TL;DR: In this paper, the diarylimidazolium salts were directly synthesized starting from 1 H -imidazole by a one-pot strategy using diaryliodonium salts as the arylating reagents.