Lei Xing
University of Ottawa
13 Papers
66 Citations
Lei Xing is an academic researcher from University of Ottawa. The author has contributed to research in topics: Neurogenesis & Radial glial cell. The author has an hindex of 8, co-authored 13 publications. Previous affiliations of Lei Xing include Max Planck Society.
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Papers
Radial glial cell: critical functions and new perspective as a steroid synthetic cell.
TL;DR: The expression of steroidogenic acute regulatory protein and the key enzyme cytochrome P450 17alpha-hydroxylase in primary cultures of goldfish RGCs indicate the potential to produce 17α-hydroxy-pregnenolone and thus other steroid intermediates, and the possibility of synthesizing additional non-estrogenic steroids may indicate new functions for the RGC.
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Dopamine D1 receptor activation regulates the expression of the estrogen synthesis gene aromatase B in radial glial cells.
Lei Xing,Heather McDonald,Dillon F. Da Fonte,Juan Manuel Gutierrez-Villagomez,Vance L. Trudeau +4 more
TL;DR: Evidence for neuronal-glial interactions via a novel role for dopamine to stimulate RGC function is provided through a cyclic adenosine monophosphate-dependent molecular mechanism and data indicate that dopamine enhances the steroidogenic function of this neuronal progenitor cell.
Stimulatory effect of the secretogranin-ll derived peptide secretoneurin on food intake and locomotion in female goldfish (Carassius auratus).
TL;DR: Interactions of SNa with stimulatory and inhibitory pathways of food intake control in fish are suggested, suggesting a potential new role of SN in goldfish feeding.
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Secretoneurin-A inhibits aromatase B (cyp19a1b) expression in female goldfish (Carassius auratus) radial glial cells.
TL;DR: Evidence is provided that SNa can regulate aromatase expression in goldfish RGCs and may be implicated in the control of major estrogen-dependent functions of the preoptic region such as reproductive behavior and osmoregulation.
15
Transcriptome Analysis Reveals That Naphthenic Acids Perturb Gene Networks Related to Metabolic Processes, Membrane Integrity, and Gut Function in Silurana (Xenopus) tropicalis Embryos
Juan Manuel Gutierrez-Villagomez,Christopher J. Martyniuk,Lei Xing,Valerie S. Langlois,Bruce D. Pauli,Jules M. Blais,Vance L. Trudeau +6 more
TL;DR: The data suggest that NAs have multiple modes of action to induce developmental toxicity in amphibians, and some modes ofaction may be shared between commercial NAs and AEOs.