Lei Wang
Xuzhou Medical College
7 Papers
4 Citations
Lei Wang is an academic researcher from Xuzhou Medical College. The author has contributed to research in topics: Diabetic nephropathy & Chemistry. The author has an hindex of 3, co-authored 5 publications.
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Papers
Novel biphenyl diester derivative AB-38b inhibits NLRP3 inflammasome through Nrf2 activation in diabetic nephropathy
Lei Du,Jin Wang,Yibing Chen,Xizhi Li,Lei Wang,Yuan Li,Xiaoping Jin,Xiaoke Gu,Meng Hao,Xia Zhu,Xiaoxing Yin,Qian Lu +11 more
TL;DR: Administration of AB-38b improved the kidney function while attenuated renal fibrosis progression in diabetic mice together with reducing the extracellular matrix (ECM) accumulation of GMCs cultured in high glucose and further exploration indicate that Nrf2 plays pivotal role in AB- 38b’s attenuation of DN progression through inhibiting NLRP3 inflammasome activation.
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A novel compound AB38b attenuates oxidative stress and ECM protein accumulation in kidneys of diabetic mice through modulation of Keap1/Nrf2 signaling.
Lei Du,Lei Wang,Bo Wang,Jin Wang,Meng Hao,Yibing Chen,Xizhi Li,Yuan Li,Jiang Yanfei,Chengcheng Li,Hao Yang,Xiaoke Gu,Xiaoxing Yin,Qian Lu +13 more
TL;DR: It is demonstrated that AB38b ameliorates experimental DN through antioxidation and modulation of Keap1/Nrf2 signaling pathway and effectively suppressed the ubiquitination of Nrf2.
Jinhua Qinggan granules attenuates acute lung injury by promotion of neutrophil apoptosis and inhibition of TLR4/MyD88/NF-κB pathway
Yanhui Zhu,Qianqian Han,Lei Wang,Baiyan Wang,Jianshuang Chen,Bangrong Cai,Can Wu,Xiali Zhu,Fugang Liu,Deen Han,H. Dong,Yongyan Jia,Yalin Liu +12 more
TL;DR: Wang et al. as mentioned in this paper investigated the effects of Jinhua Qinggan granules (JHQG) on neutrophil apoptosis and key signaling pathways in lipopolysaccharide (LPS) -induced acute lung injury (ALI) mice in order to explore its mechanism of anti-inflammation.
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Inactivation of TSC1 promotes epithelial-mesenchymal transition of renal tubular epithelial cells in mouse diabetic nephropathy.
Qian Lu,Yibing Chen,Hao Yang,Wen-wen Wang,Chengcheng Li,Lei Wang,Jin Wang,Lei Du,Xiaoxing Yin +8 more
TL;DR: It is found that the exposure of HK-2 cells to HG time-dependently decreased TSC1 expression, increased the phosphorylation of mTORC1, P70S6K, and 4E-BP-1, and promoted cell migration, resulting in EMT.
Correction to: novel biphenyl diester derivative AB-38b inhibits NLRP3 inflammasome through Nrf2 activation in diabetic nephropathy.
Lei Du,Jin Wang,Yibing Chen,Xizhi Li,Lei Wang,Yuan Li,Xiaoping Jin,Xiaoke Gu,Meng Hao,Xia Zhu,Xiaoxing Yin,Qian Lu +11 more
TL;DR: There are some tiny errors in the data for Fig. 1a-c and Fig. 2a-e, but these errors does not interfere the results and conclusions of authors study.