Lei Song
Shanghai Jiao Tong University
9 Papers
28 Citations
Lei Song is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Biology & Hair cell. The author has an hindex of 4, co-authored 4 publications.
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Papers
Simultaneous zygotic inactivation of multiple genes in mouse through CRISPR/Cas9-mediated base editing.
He Zhang,Hong Pan,Hong Pan,Changyang Zhou,Yu Wei,Wenqin Ying,Shuting Li,Guangqin Wang,Chao Li,Yifei Ren,Gen Li,Xu Ding,Yidi Sun,Yidi Sun,Geng Lin Li,Lei Song,Yixue Li,Hui Yang,Zhiyong Liu +18 more
TL;DR: It is believed that CRISPR-stop is a powerful method that will pave the way for high-throughput screening of mouse developmental and functional genes, matching the efficiency of methods available for model organisms such as Drosophila.
56
Role of mitochondrial dysfunction and oxidative stress in sensorineural hearing loss
Winston Tan,Lei Song +1 more
TL;DR: In this article , the authors provide an overview of the current knowledge on the role of mitochondrial dysfunction and oxidative stress in the development of sensorineural hearing loss caused by genetic mutations, aging, exposure to excessive noise, and ototoxic drugs.
49
Characterizing a novel vGlut3-P2A-iCreER knockin mouse strain in cochlea
TL;DR: vGlut3‐P2A‐iCreER is an efficient genetic tool to specifically target IHCs for gene manipulation, which is complimentary to Prestin‐CreER strain exclusively labelling cochlear outer hair cells (OHCs).
43
Functional alteration of ribbon synapses in inner hair cells by noise exposure causing hidden hearing loss.
TL;DR: Moderate noise exposure to mice and combined auditory systems physiology, whole-mount immunofluorescence staining and patch-clamp electrophysiology suggest temporary and persistent alterations of ribbon synapse functions in IHCs contribute to the hidden hearing loss.
33
Defective mechanosensory transduction of the new inner hair cells prevents hearing recover in the damaged cochlea
Xiang Li,Minhui Ren,Yunpeng Gu,T. Zhu,Yu Zhang,Jie Liu,Chao Li,Guangqin Wang,Lei Song,Zhenghong Bi,Zhiyong Liu +10 more
TL;DR: In this article , the inner hair cells (IHCs), the primary sound receptors innervated by the auditory neurons, were specifically damaged and the neighboring nonsensory supporting cells (SCs) were transformed into IHCs by ectopic expression of transient Atoh1 and permanent Tbx2.