Lei Lu
Nanjing University
12 Papers
6 Citations
Lei Lu is an academic researcher from Nanjing University. The author has contributed to research in topics: Wnt signaling pathway & Xenopus. The author has an hindex of 8, co-authored 10 publications. Previous affiliations of Lei Lu include Fudan University & Chinese Academy of Sciences.
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Papers
PHF7 is a novel histone H2A E3 ligase prior to histone-to-protamine exchange during spermiogenesis.
Xiukun Wang,Jun-Yan Kang,Leixin Wei,Leixin Wei,Xiaogan Yang,Hongduo Sun,Suming Yang,Lei Lu,Meng Yan,Meizhu Bai,Yanyan Chen,Juanjuan Long,Na Li,Dangsheng Li,Jing Huang,Ming Lei,Zhen Shao,Wen Yuan,Erwei Zuo,Kehuan Lu,Mo-Fang Liu,Jinsong Li +21 more
TL;DR: This study reveals that PHF7 is a novel E3 ligase that can specifically ubiquitylate H2A through binding H3K4me3/me2 prior to histone-to-protamine exchange in mouse spermiogenesis.
Regulation of DLK1 by the maternally expressed miR-379/miR-544 cluster may underlie callipyge polar overdominance inheritance.
Yun-Qian Gao,Xin Chen,Pei Wang,Lei Lu,Wei Zhao,Chen Chen,Cai-Ping Chen,Tao Tao,Jie Sun,Yan-Yan Zheng,Jie Du,Chao-Jun Li,Zhenji Gan,Xiang Gao,Hua-Qun Chen,Min-Sheng Zhu +15 more
TL;DR: The results showed that the maternally expressed miR-379/miR-544 cluster might regulate skeletal muscle growth through the imprinted Delta-like 1 homolog (Dlk1) gene in mice, revealing a molecular mechanism of the polar overdominance inheritance.
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Kruppel-like factor family genes are expressed during Xenopus embryogenesis and involved in germ layer formation and body axis patterning
TL;DR: The results suggest that Klf factors are involved in the fine‐tuning of these genes during early embryogenesis, as well as in the regulation of key developmental signals.
23
Novel mutations of AXIN2 identified in a Chinese Congenital Heart Disease Cohort.
Mengjiao Zhu,Xiaoyun Ma,Pei-Cheng Ding,Han-Fei Tang,Rui Peng,Lei Lu,Peiqiang Li,Bin Qiao,Xue-Yan Yang,Yufang Zheng,Hongyan Wang,Yun-Qian Gao,Fengshan Chen +12 more
TL;DR: This study finds a differential expression of Axin2 mRNA during the development of mouse heart, indicating its importance in mouse cardiac development and indicates that rare mutations in AXIN2 might contribute to the risk of human CHDs and a balanced canonical Wnt pathway is critical for cardiac development process.
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Deleterious Rare Mutations of GLI1 Dysregulate Sonic Hedgehog Signaling in Human Congenital Heart Disease
Rui Peng,Bin-Bin Li,Shuxia Chen,Zhiwen Shi,Liwei Yu,Yunqian Gao,Xue-Yan Yang,Lei Lu,Hongyan Wang +8 more
TL;DR: It is suggested that deleterious rare mutations in GLI1 gene broke the balance of the SHH signaling pathway regulation and may constitute a great contribution to human CHD, which shed new light on understanding genetic mechanism of embryo cardiogenesis regulated bySHH signaling.