7 Papers
21 Citations
Lei Li is an academic researcher from Huazhong University of Science and Technology. The author has contributed to research in topics: Gene knockdown & Chemistry. The author has an hindex of 5, co-authored 7 publications.
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Papers
Delivery of miR-375 and doxorubicin hydrochloride by lipid-coated hollow mesoporous silica nanoparticles to overcome multiple drug resistance in hepatocellular carcinoma
Huiying Xue,Zhaoyang Yu,Yong Liu,Weigang Yuan,Tan Yang,Jia You,Xing-Xing He,Robert J. Lee,Lei Li,Chuanrui Xu +9 more
TL;DR: This study illustrates that delivery of miR-375 using HMSN is a feasible approach to circumvent MDR in the management of HCC and merits further development for potential clinical application.
Gold nanoparticles delivered miR-375 for treatment of hepatocellular carcinoma
Huiying Xue,Yong Liu,Jia-Zhi Liao,Ju-Sheng Lin,Bin Li,Weigang Yuan,Robert J. Lee,Lei Li,Chuanrui Xu,Xing-Xing He +9 more
TL;DR: The findings indicate that AuNPs is a reliable strategy to deliver miR-375 into HCC cells and tissue, and that AuNP-miR- 375 has the potential in the clinic for treatment of unresectable HCC.
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Bmi1 drives hepatocarcinogenesis by repressing the TGFβ2/SMAD signalling axis.
Bin Li,Yuyuan Chen,Fei Wang,Jun Guo,Wen Fu,Min Li,Qichang Zheng,Yong Liu,Lingling Fan,Lei Li,Chuanrui Xu +10 more
TL;DR: The findings elucidate the molecular mechanism underlying hepatic Bmi1-driven carcinogenesis and highlight the importance of TGFβ2 as a tumour suppressor in HCC development.
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Targeting ROCK1/2 blocks cell division and induces mitotic catastrophe in hepatocellular carcinoma.
Hua Wu,Yuyuan Chen,Bin Li,Chun Li,Jun Guo,Jia You,Xian Hu,Dong Kuang,Shibo Qi,Pin Liu,Lei Li,Chuanrui Xu +11 more
TL;DR: Both ROCK1 and ROCK2 are required for HCC cell division and growth and targeting ROCK1 or ROCK2 rather than both can serve as a potential approach for H CC treatment and may reduce the side effects.
17
Validation of Bmi1 as a Therapeutic Target of Hepatocellular Carcinoma in Mice
TL;DR: It is shown that perturbation of Bmi1 expression by using short hairpin RNA can inhibit the tumorigenicity and tumor growth of hepatocellular carcinoma cells both in vitro and in vivo.
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