33 Papers
111 Citations
Lei Li is an academic researcher from University of California, Irvine. The author has contributed to research in topics: Gene & Quantitative trait locus. The author has an hindex of 15, co-authored 33 publications. Previous affiliations of Lei Li include The Chinese University of Hong Kong & Baylor College of Medicine.
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Papers
In Vivo Cleavage Map Illuminates the Central Role of RNase E in Coding and Non-coding RNA Pathways.
Yanjie Chao,Lei Li,Dylan Girodat,Konrad U. Förstner,Nelly Said,Colin P. Corcoran,Michał Śmiga,Kai Papenfort,Kai Papenfort,Richard Reinhardt,Hans-Joachim Wieden,Bonaventura Francesco Luisi,Jörg Vogel +12 more
TL;DR: The results suggest a prominent biogenesis pathway for bacterial regulatory small RNAs whereby RNase E acts together with the RNA chaperone Hfq to liberate stable 3′ fragments from various precursor RNAs, and reveal a general maturation mechanism for a major class of post-transcriptional regulators.
261
Single-cell RNA-seq ties macrophage polarization to growth rate of intracellular Salmonella
Antoine-Emmanuel Saliba,Lei Li,Alexander J. Westermann,Silke Appenzeller,Daphne A.C. Stapels,Leon N. Schulte,Sophie Helaine,Jörg Vogel +7 more
TL;DR: The data suggest that gene expression variability in infected host cells shapes different cellular environments, some of which may favour a growth arrest of Salmonella facilitating immune evasion and the establishment of a long-term niche, while others allowSalmonella to escape intracellular antimicrobial activity and proliferate.
185
Global Maps of ProQ Binding In Vivo Reveal Target Recognition via RNA Structure and Stability Control at mRNA 3' Ends.
TL;DR: The results underpin the notion that ProQ governs a post-transcriptional network distinct from those of the well-characterized s RNA-binding proteins, CsrA and Hfq, and suggest a previously unrecognized, sRNA-independent role of ProQ in stabilizing mRNAs.
142
An atlas of alternative polyadenylation quantitative trait loci contributing to complex trait and disease heritability.
Lei Li,Kai Lieh Huang,Yipeng Gao,Ya Cui,Gao Wang,Nathan D. Elrod,Yumei Li,Yiling Elaine Chen,Ping Ji,Fanglue Peng,William K. Russell,Eric J. Wagner,Wei Li +12 more
TL;DR: In this paper, a multi-tissue atlas of human 3'UTR alternative polyadenylation (APA) quantitative trait loci (3'aQTLs) was constructed, containing approximately 0.4 million common genetic variants associated with the APA of target genes.
128
BSRD: a repository for bacterial small regulatory RNA
TL;DR: BSRD is developed, a comprehensive bacterial sRNAs database, as a repository for published bacterial sRNA sequences with annotations and expression profiles, and a novel RNA-Seq analysis platform, sRNADeep, to characterize s RNAs in large-scale transcriptome sequencing projects.