16 Papers
81 Citations
Lei Li is an academic researcher from South University of Science and Technology of China. The author has contributed to research in topics: Trifluoromethylation & Chemistry. The author has an hindex of 9, co-authored 16 publications. Previous affiliations of Lei Li include South University & Southern University of Science and Technology.
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Papers
Enantioselective C-H bond functionalization triggered by radical trifluoromethylation of unactivated alkene.
TL;DR: An asymmetric unactivated alkene/C-H bond difunctionalization reaction for the concomitant construction of C-CF3 and C-O bonds was realized by using a Cu/Brønsted acid cooperative catalytic system, thus providing facile access to valuable chiral CF3-containing N,O-aminals with excellent regio-, chemo-, and enantioselectivity.
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Radical aryl migration enables diversity-oriented synthesis of structurally diverse medium/macro- or bridged-rings
Lei Li,Zhong-Liang Li,Fu-Li Wang,Zhen Guo,Yong-Feng Cheng,Na Wang,Xiaowu Dong,Chao Fang,Jingjiang Liu,Chunhui Hou,Bin Tan,Xin-Yuan Liu +11 more
TL;DR: A radical-based approach for diversity-oriented synthesis of various benzannulated carbon- and heteroatom-containing 8–11(14)-membered ketone libraries is disclosed, which showed potent inhibitory activity against the cancer cell or derivative of human embryonic kidney line in preliminary biological studies.
A remote C-C bond cleavage-enabled skeletal reorganization: Access to medium-/large-sized cyclic alkenes.
TL;DR: A novel C–C bond reorganization strategy via an unprecedented radical 1,3-, 1,4-, or 1,5-vinyl migration triggered by various types of fluoroalkylation of alkenes for the efficient realization of 1,2-fluoroalksylalkenylation reaction.
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Catalytic Diverse Radical-Mediated 1,2-Cyanofunctionalization of Unactivated Alkenes via Synergistic Remote Cyano Migration and Protected Strategies
TL;DR: A catalytic radical protocol for 1,2-cyanofunctionalization of unactivatedAlkenes involving remote cyano migration triggered by addition of diverse carbon- and heteroatom-centered radicals to alkenes has been developed.
84
1,2-Difunctionalization-type (hetero)arylation of unactivated alkenes triggered by radical addition/remote (hetero)aryl migration.
TL;DR: A novel difunctionalization-type (hetero)arylation of unactivated alkenes has been developed via remote 1,4(5)-( hetero)aryl migration triggered by radical alkene azidation, trifluoromethylation, or phosphonylation.
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