Lei Dong
Dalian Medical University
9 Papers
9 Citations
Lei Dong is an academic researcher from Dalian Medical University. The author has contributed to research in topics: Cancer cell & Cell migration. The author has an hindex of 7, co-authored 9 publications.
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Papers
Circulating MiR-125b as a Marker Predicting Chemoresistance in Breast Cancer
TL;DR: It is suggested that circulating miR-125b expression is associated with chemotherapeutic resistance of breast cancer, which has important implications in the development of targeted therapeutics for overcoming chemotherAPEutic resistance in novel anti-cancer strategies.
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Autophagy promotes metastasis and glycolysis by upregulating MCT1 expression and Wnt/β-catenin signaling pathway activation in hepatocellular carcinoma cells
Qing Fan,Liang Yang,Xiaodong Zhang,Yingbo Ma,Yan Li,Lei Dong,Zhi-Hong Zong,Xiangdong Hua,Dongming Su,Hangyu Li,Jingang Liu +10 more
TL;DR: The connection between autophagy and glucose metabolism in HCC cells is described and may provide a potential therapeutic target for HCC treatment.
Lysine-specific demethylase 5C promotes hepatocellular carcinoma cell invasion through inhibition BMP7 expression.
TL;DR: In this article, KDM5C is abundantly expressed in invasive human hepatocellular carcinoma (HCC) cells and ectopic expression in HCC cells promoted cell migration, invasion and epithelial-mesenchymal transition via inactivation of BMP7.
HOXB9 promotes epithelial-to-mesenchymal transition via transforming growth factor-β1 pathway in hepatocellular carcinoma cells.
TL;DR: This study is the first to illustrate the pivotal function of HOXB9 in regulating the metastatic behavior of HCC cells, and demonstrates that the TGF-β1 pathway is important in HOxB9-induced EMT in H CC cells.
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Somatic mutations in myeloid cell leukemia-1 contribute to the pathogenesis of glioma by prolonging its half-life.
TL;DR: The mutational profiling of GBM revealed for the first time, to the best of the authors' knowledge, several mutations in Mcl-1, and identified this gene as a novel therapeutic target for the treatment of G BM.