Lee Warren

TL;DR: To identify novel Asc-1 inhibitors, two different screening approaches were performed with whole-cell amino acid uptake in heterologous cells stably expressing human Asc- 1, and the implementation of counter screens to remove nonspecific inhibitors of radioactive amino acids uptake was implemented.

TL;DR: Systemic administration of BNC375 reverses scopolamine-induced cognitive deficits in rat novel object recognition and rhesus monkey object retrieval detour task over a wide range of exposures, showing no evidence of an inverted U-shaped dose-effect curve and suggesting that α7 nAChR PAMs have therapeutic potential in central nervous system diseases with cognitive impairments.

TL;DR: In this paper, the discovery of 10 single nucleotide polymorphisms in the human mGluR8 gene was discussed, and methods and materials for analyzing allelic variation in the mGliR8 genes were presented.

TL;DR: A unique cylcyclohexyldiamine scaffold was identified that led to remarkable improvements in potency, opening up opportunities to reduce MW, Pgp efflux and improve pharmacokinetic properties while also conferring improved solubility.