Lee M. Ellis
University of Texas MD Anderson Cancer Center
364 Papers
5.3K Citations
Lee M. Ellis is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor. The author has an hindex of 105, co-authored 355 publications.
Chat about Author
Papers
The role of neuropilins in cancer
TL;DR: Neuropilins are multifunctional non-tyrosine kinase receptors that bind to class 3 semaphorins and vascular endothelial growth factor and have been found to play key roles in mediating axonal guidance in the developing nervous system as mentioned in this paper.
•Journal Article
Regulation of vascular endothelial growth factor expression in human colon carcinoma cells by cell density
TL;DR: The data suggest that VEGF expression may be regulated by an unidentified soluble factor, and the effect of cell density on vascular endothelial growth factor expression is determined.
Endothelial Cells Promote Colorectal Cancer Cell Survival by Activating the HER3-AKT Pathway in a Paracrine Fashion
TL;DR: A paracrine role of liver ECs in promoting cell growth and chemoresistance via activating HER3-AKT in colorectal cancer cells is demonstrated and a potential of treating patients with metastatic coloreCTal cancer with HER3 antibodies/inhibitors that are currently being assessed in clinical trials is suggested.
Neuropilin-1 in human colon cancer: expression, regulation, and role in induction of angiogenesis.
Alexander A. Parikh,Fan Fan,Wen Biao Liu,Syed A. Ahmad,Oliver Stoeltzing,Niels Reinmuth,Diane R. Bielenberg,Corazon D. Bucana,Michael Klagsbrun,Lee M. Ellis +9 more
TL;DR: It is suggested that EGF and mitogen-activated protein kinase signaling pathways play an important role in NRP-1 regulation in colon cancer cells and may contribute to colon cancer angiogenesis and growth.
Overview of angiogenesis: Biologic implications for antiangiogenic therapy
Lee M. Ellis,Wenbiao Liu,Syed A. Ahmad,Fan Fan,Young Do Jung,Raymond M. Shaheen,Niels Reinmuth +6 more
TL;DR: Understanding the basic principles that drive tumor angiogenesis will lead to the development of therapies that will likely prolong survival without the toxicity associated with standard chemotherapy.