Lee Koetzner
Purdue Pharma
10 Papers
89 Citations
Lee Koetzner is an academic researcher from Purdue Pharma. The author has contributed to research in topics: ATP synthase & ATP synthase gamma subunit. The author has an hindex of 8, co-authored 10 publications.
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Papers
Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy.
Kenneth J. Valenzano,Laykea Tafesse,Gary Lee,James E. Harrison,Jamie Boulet,Susan L. Gottshall,Lilly Mark,Michelle S. Pearson,Wendy S. Miller,Shen Shan,Leyana Rabadi,Yakov Rotshteyn,Suzanne M. Chaffer,Paul I. Turchin,David A. Elsemore,Mathew Toth,Lee Koetzner,Garth Whiteside +17 more
TL;DR: Data support the tenet that selective CB2 receptor agonists have the potential to treat pain without eliciting the centrally-mediated side effects associated with non-selective cannabinoid agonists, and highlight the utility of GW405833 for the investigation of CB2 physiology.
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Plant-Derived Polysaccharide Supplements Inhibit Dextran Sulfate Sodium-Induced Colitis in the Rat
TL;DR: Ambrotose and Advanced Ambrotose significantly lowered the disease scores and partially prevented the shortening of colon length in rats and the mechanism of action of the formulations against DSS-induced colitis may be related to its effect on monocyte count.
The soluble fiber complex PolyGlycopleX lowers serum triglycerides and reduces hepatic steatosis in high-sucrose-fed rats.
TL;DR: It is hypothesized that consumption of PGX would attenuate hypertriglyceridemia and reduce hepatic steatosis compared with cellulose in rats fed a high-sucrose background diet and in conclusion, PGX reduced serum TG and lipid accumulation in the liver of sucrose-fed rats.
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Energetic signalling in the control of mitochondrial F1F0 ATP synthase activity in health and disease.
TL;DR: Selective hydrolase inhibition seen with the small molecule BMS-199264 suggests a conformational change in the F1F0 ATPase enzyme when switching from synthase to hydrol enzyme activity.
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Rapid and sensitive determination of acetylsalicylic acid and salicylic acid in plasma using liquid chromatography–tandem mass spectrometry: application to pharmacokinetic study
TL;DR: The developed method was successfully applied for the evaluation of pharmacokinetics of ASA and SA after p.o. and i.v. administration of 1 mg/kg to rats.
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