Lea Tunisi
National Research Council
10 Papers
28 Citations
Lea Tunisi is an academic researcher from National Research Council. The author has contributed to research in topics: Dentate gyrus & Orexin. The author has an hindex of 3, co-authored 9 publications. Previous affiliations of Lea Tunisi include University of Naples Federico II.
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Papers
Ultra-micronized palmitoylethanolamide rescues the cognitive decline-associated loss of neural plasticity in the neuropathic mouse entorhinal cortex-dentate gyrus pathway.
Serena Boccella,Claudia Cristiano,Rosaria Romano,Monica Iannotta,Carmela Belardo,Antonio Farina,Francesca Guida,Fabiana Piscitelli,Enza Palazzo,Mariacristina Mazzitelli,Roberta Imperatore,Lea Tunisi,Vito de Novellis,Luigia Cristino,Vincenzo Di Marzo,Antonio Calignano,Sabatino Maione,Livio Luongo +17 more
TL;DR: It is suggested that neuropathic pain negatively affects cognitive behavior and related LTP, glutamatergic synapse and synaptogenesis in the DG, and PEA treatment alleviates pain and cognitive impairment by restoring LTP and synaptic maladaptative changes in the LEC-DG pathway.
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Orexin-A and endocannabinoids are involved in obesity-associated alteration of hippocampal neurogenesis, plasticity, and episodic memory in mice.
Nicola Forte,Serena Boccella,Lea Tunisi,Alba Clara Fernández-Rilo,Roberta Imperatore,Fabio Arturo Iannotti,Maria De Risi,Monica Iannotta,Fabiana Piscitelli,Raffaele Capasso,Paolo de Girolamo,Elvira De Leonibus,Sabatino Maione,Vincenzo Di Marzo,Luigia Cristino +14 more
TL;DR: This paper showed that excessive orexin-A/2-arachidonoylglycerol/cannabinoid receptor type-1 signaling leads to the dysfunction of adult hippocampal neurogenesis and the subsequent inhibition of plasticity and impairment of pattern separation.
N-palmitoyl-D-glucosamine, a Natural Monosaccharide-Based Glycolipid, Inhibits TLR4 and Prevents LPS-Induced Inflammation and Neuropathic Pain in Mice.
Monica Iannotta,Carmela Belardo,Maria Consiglia Trotta,Fabio Arturo Iannotti,Rosa Maria Vitale,Rosa Maisto,Serena Boccella,Rosmara Infantino,Flavia Ricciardi,Benito Fabio Mirto,Franca Ferraraccio,Iacopo Panarese,Pietro Amodeo,Lea Tunisi,Luigia Cristino,Michele D'Amico,Vincenzo Di Marzo,Vincenzo Di Marzo,Livio Luongo,Sabatino Maione,Francesca Guida +20 more
TL;DR: In this article, N-palmitoyl-d-glucosamine (PGA) was used to prevent LPS-induced tissue damage or even peripheral neuropathies.
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Altered heparan sulfate metabolism during development triggers dopamine-dependent autistic-behaviours in models of lysosomal storage disorders
Maria De Risi,Michele Tufano,Filomena Grazia Alvino,Maria Grazia Ferraro,Giulia Torromino,Ylenia Gigante,Jlenia Monfregola,Elena Marrocco,Salvatore Pulcrano,Lea Tunisi,Claudia Lubrano,Dulce Papy-Garcia,Yaakov Tuchman,Alberto Salleo,Francesca Santoro,Gian Carlo Bellenchi,Luigia Cristino,Andrea Ballabio,Alessandro Fraldi,Elvira De Leonibus +19 more
TL;DR: This article found that autistic-like behaviors are due to increased proliferation of mesencephalic dopamine neurons originating during embryogenesis, which is not due to lysosomal dysfunction, but to altered HS function.
OC.6- Ultra-micronized palmitoylethanolamide rescues the cognitive decline-associated loss of neural plasticity in the neuropathic mouse entorhinal cortex-dentate gyrus pathway
Serena Boccella,Claudio Cristiano,Rosaria Romano,Monica Iannotta,Carmela Belardo,Antonio Farina,Francesca Guida,Fabiana Piscitelli,Enza Palazzo,Mariacristina Mazzitelli,Roberta Imperatore,Lea Tunisi,Vito De Novellisa,Luigia Cristino,Vincenzo Di Marzo,Antonio Calignano,Sabatino Maione,Livio Luongo,Naples +18 more
- 01 Jan 2019
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