Lea Mann
11 Papers
Lea Mann is an academic researcher. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 2, co-authored 8 publications.
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Papers
Mechanism of mycobacterial ATP synthase inhibition by squaramides and second generation diarylquinolines.
TL;DR: In this article , the authors used electron microscopy and biochemical assays to study the interaction of Mycobacterium smegmatis ATP synthase with the second generation diarylquinoline TBAJ-876 and the squaramide inhibitor SQ31f.
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Synthesis and Characterization of Phenylalanine Amides Active against Mycobacterium abscessus and Other Mycobacteria.
Markus Lang,Uday S. Ganapathy,Lea Mann,Rana Abdelaziz,Rüdiger W. Seidel,Richard Goddard,Sophie Hoenke,Philipp Schulze,W. W. Aragaw,René Csuk,Thomas Dick,Adrian Richter +11 more
TL;DR: In this article , the authors described derivatization of MMV688845 by introducing a thiomorpholine moiety and the preparation of corresponding sulfones and sulfoxides.
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BTZ-Derived Benzisothiazolinones with In Vitro Activity against Mycobacterium tuberculosis.
Adrian Richter,Rüdiger W. Seidel,Richard Goddard,Tamira Eckhardt,Christoph Lehmann,Julia Dörner,Fabienne Siersleben,Theresia Sondermann,Lea Mann,Michael Patzer,Christiane Jäger,Norbert Reiling,Peter Imming +12 more
TL;DR: Molecular covalent docking of the new compounds to Mycobacerium tuberculosis decaprenylphosphoryl-β-d-ribose 2'-epimerase (DprE1) suggests that the active BITs exert antimycobacterial activity through inhibition of DPRE1 like BTZs.
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Structure-Activity Relationship of Anti-Mycobacterium abscessus Piperidine-4-carboxamides, a New Class of NBTI DNA Gyrase Inhibitors.
Andreas Beuchel,Dina Robaa,Dereje Abate Negatu,Abdeldjalil Madani,Nadine Alvarez,Matthew C. Zimmerman,Adrian Richter,Lea Mann,Sophie Hoenke,René Csuk,Thomas Dick,Peter Imming +11 more
TL;DR: This work suggests that P4Cs present a novel structural subclass of NBTI, similar to gepotidacin, which is a member of the Novel Bacterial Topoisomerase Inhibitors (NBTIs), a new class of nonfluoroquinolone DNA gyrase poisons.
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Synthesis and in vitro metabolic stability of sterically shielded antimycobacterial phenylalanine amides.
Markus Lang,Uday S. Ganapathy,Lea Mann,Rüdiger W. Seidel,Richard Goddard,Frank Erdmann,Thomas Dick,Adrian Richter +7 more
TL;DR: Stability data are discussed in relation to the antimycobacterial activity of the panel of compounds and reveal that the concept of steric shielding of the anilide groups by a fluoro substituent has the potential to improve the stability and bioavailability of AAPs.
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