Le Yu
Genentech
5 Papers
10 Citations
Le Yu is an academic researcher from Genentech. The author has contributed to research in topics: Nanopore sequencing & Gene. The author has an hindex of 2, co-authored 5 publications.
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Papers
A Confirmed Case of SARS-CoV-2 Pneumonia With Negative Routine Reverse Transcriptase-Polymerase Chain Reaction and Virus Variation in Guangzhou, China.
Zhengtu Li,Li Yinhu,Lingdan Chen,Shaoqiang Li,Le Yu,Airu Zhu,Feng Yang,Qian Jiang,Liyan Chen,Jincun Zhao,Wenju Lu,Nanshan Zhong,Feng Ye +12 more
TL;DR: This case has highlighted that false negative results could be present in the routine RT-PCR diagnosis, especially with virus variation, and Nanopore pathogen sequencing and antibody detection have been found effective in clinical diagnosis.
Alteration of the respiratory microbiome in COVID-19 patients with different severities.
Weiping Cai,Zhengtu Li,Yinhu Li,Vicente Timón,Manuel Queisser,Linghua Li,Xiaoneng Mo,Shaoqiang Li,Mingzhou Xie,Yangqing Zhan,Ye Lin,Zhun Li,Min Xie,Zhaoming Chen,Airu Zhu,Ruosu Ying,Le Yu,Jincun Zhao,Shuai Cheng Li,Weiping Cai,Feng Ye +20 more
10
Longitudinal virological changes and underlying pathogenesis in hospitalized COVID-19 patients in Guangzhou, China.
Zhengtu Li,Yinhu Li,Ruilin Sun,Shaoqiang Li,Lingdan Chen,Zhan Yangqing,Mingzhou Xie,Jiasheng Yang,Yanqun Wang,Airu Zhu,Guoping Gu,Le Yu,Shuai Cheng Li,Liu Tingting,Zhaoming Chen,Wenhua Jian,Qian Jiang,Xiaofen Su,Weili Gu,Liyan Chen,Jing Cheng,Jincun Zhao,Wenju Lu,Jinping Zheng,Shiyue Li,Nanshan Zhong,Feng Ye +26 more
TL;DR: In this paper, the authors found that the average viral shedding time in severe/critical patients was more than 50 days, and up to 100 days in some patients, after symptom onset.
Patent
Specific primer for novel coronary virus detection and rapid detection method
Feng Ye,Zhengtu Li,Le Yu,Lingdan Chen,Lu Wenju,Liu Tingting,Li Yinhu,Zhao Zhiqiang,Shaoqiang Li,Zhan Yangqing,Jing Cheng,Liyan Chen +11 more
- 30 Jun 2020
TL;DR: In this paper, a specific primer for novel coronary virus detection and a rapid detection method was disclosed. And the method comprises the following steps of inactivating a collected sample, and extracting virus RNA; carrying out inversion on virus RNA which is extracted in the step S1 and qualified through quality testing to perform cDNA synthesis.
2
CovProfile: profiling the viral genome and gene expressions of SARS-COV2
TL;DR: A computational tool CovProfile is proposed to detect the viral genomic variations as well as viral gene expressions from the sequences obtained from Nanopore devices and it is discovered that all the patients are infected by multiple viral strains, which might affect the reliability of phylogenetic analysis.