Since Facebook was renamed Meta, a lot of attention, debate, and exploration have intensified about what the Metaverse is, how it works, and the possible ways to exploit it. It is anticipated that Metaverse will be a continuum of rapidly emerging technologies, usecases, capabilities, and experiences that will make it up for the next evolution of the Internet. Several researchers have already surveyed the literature on artificial intelligence (AI) and wireless communications in realizing the Metaverse. However, due to the rapid emergence and continuous evolution of technologies, there is a need for a comprehensive and in-depth survey of the role of AI, 6G, and the nexus of both in realizing the immersive experiences of Metaverse. Therefore, in this survey, we first introduce the background and ongoing progress in augmented reality (AR), virtual reality (VR), mixed reality (MR) and spatial computing, followed by the technical aspects of AI and 6G. Then, we survey the role of AI in the Metaverse by reviewing the state-of-the-art in deep learning, computer vision, and Edge AI to extract the requirements of 6G in Metaverse. Next, we investigate the promising services of B5G/6G towards Metaverse, followed by identifying the role of AI in 6G networks and 6G networks for AI in support of Metaverse applications, and the need for sustainability in Metaverse. Finally, we enlist the existing and potential applications, usecases, and projects to highlight the importance of progress in the Metaverse. Moreover, in order to provide potential research directions to researchers, we underline the challenges, research gaps, and lessons learned identified from the literature review of the aforementioned technologies. 

AI and 6G Into the Metaverse: Fundamentals, Challenges and Future Research Trends

Central Nervous System Diseases are a leading cause of disability worldwide, posing significant social and economic burdens for patients, their families, caregivers, and society as a whole [...].

https://www.mdpi.com/2076-3425/13/5/819/pdf?version=1684410113

Virtual Reality Applications in Neurorehabilitation: Current Panorama and Challenges

Intelligent transportation systems (ITS) have made significant advancements in enhancing transportation safety, reliability, and efficiency. However, challenges persist in security, privacy, data management, and integration. Metaverse, an emerging technology enabling immersive and simulated experiences, presents promising solutions to overcome these challenges. By establishing secure communication channels, facilitating virtual simulations for safe testing and training, and enabling centralized data management with real-time analytics, metaverse offers a transformative approach to address these challenges. While metaverse has found extensive applications across industries, its potential in transportation remains largely untapped. This comprehensive review delves into the integration of the metaverse in ITS, exploring key technologies like virtual reality, digital twin, blockchain, and artificial intelligence, and their specific applications in the context of ITS. Real-world case studies, research projects, and initiatives are compiled to showcase the metaverse’s potential for ITS. It also examines the societal, economic, and technological implications of metaverse integration in ITS and highlights the associated integration challenges. Lastly, future research directions are identified to unlock the metaverse’s full potential in enhancing transportation systems. 

Metaverse for Intelligent Transportation Systems (ITS): A Comprehensive Review of Technologies, Applications, Implications, Challenges and Future Directions

Background Stroke is one of the most common neurological conditions that often leads to upper limb motor impairments, significantly affecting individuals' quality of life. Rehabilitation strategies are crucial in facilitating post-stroke recovery and improving functional independence. Functional Electrical Stimulation (FES) systems have emerged as promising upper limb rehabilitation tools, offering innovative neuromuscular reeducation approaches. Objective The main objective of this paper is to provide a comprehensive systematic review of the start-of-the-art functional electrical stimulation (FES) systems for upper limb neurorehabilitation in post-stroke therapy. More specifically, this paper aims to review different types of FES systems, their feasibility testing, or randomized control trials (RCT) studies. Methods The FES systems classification is based on the involvement of patient feedback within the FES control, which mainly includes “Open-Loop FES Systems” (manually controlled) and “Closed-Loop FES Systems” (brain-computer interface-BCI and electromyography-EMG controlled). Thus, valuable insights are presented into the technological advantages and effectiveness of Manual FES, EEG-FES, and EMG-FES systems. Results and discussion The review analyzed 25 studies and found that the use of FES-based rehabilitation systems resulted in favorable outcomes for the stroke recovery of upper limb functional movements, as measured by the FMA (Fugl-Meyer Assessment) (Manually controlled FES: mean difference = 5.6, 95% CI (3.77, 7.5), P < 0.001; BCI-controlled FES: mean difference = 5.37, 95% CI (4.2, 6.6), P < 0.001; EMG-controlled FES: mean difference = 14.14, 95% CI (11.72, 16.6), P < 0.001) and ARAT (Action Research Arm Test) (EMG-controlled FES: mean difference = 11.9, 95% CI (8.8, 14.9), P < 0.001) scores. Furthermore, the shortcomings, clinical considerations, comparison to non-FES systems, design improvements, and possible future implications are also discussed for improving stroke rehabilitation systems and advancing post-stroke recovery. Thus, summarizing the existing literature, this review paper can help researchers identify areas for further investigation. This can lead to formulating research questions and developing new studies aimed at improving FES systems and their outcomes in upper limb rehabilitation.

A systematic review on functional electrical stimulation based rehabilitation systems for upper limb post-stroke recovery

BACKGROUND
Chronic disease self-management is a public health issue of worldwide concern, and gamification is an emerging strategy to improve patients' participation in chronic disease self-management. Some studies have summarized designs for the gamification of chronic disease self-management from the perspective of eHealth technology, but they have not mentioned differences in design methods, functions, and evaluation methods of gamified designs for self-management in different chronic diseases.


OBJECTIVE
This scoping review aims to synthesize the characteristics of realization forms, functions, and evaluation methods in chronic disease self-management gamification to improve self-management among the chronic disease population.


METHODS
We applied a methodological framework for scoping reviews and the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) checklist. As of January 7, 2023, we systematically searched 9 databases for relevant studies from January 2012 to December 2022. Related data were extracted based on the research questions. We calculated the frequencies, charted the quantitative data, and coded the extracted material for qualitative content analysis.


RESULTS
We retrieved 16,221 records, of which 70 (0.43%) met the eligibility criteria. In the included research, the target populations for gamified designs for self-management of chronic diseases included patients with stroke, cancer, diabetes, chronic obstructive pulmonary disease, coronary heart disease, obesity, and hypertension. Almost all studies mentioned technical support for gamification (68/70, 97%), mainly in the form of active video games (58/70, 83%); however, less than half of the studies mentioned the theoretical basis for gamification (31/70, 44%). There were 37 concepts or theories relevant to gamification design, most of which were in the field of psychology or were cross-disciplinary (n=33, 89%). Gamification for the self-management of chronic diseases has been widely recognized, including for promoting physical exercise and rehabilitation training (48/99, 48%), increasing initiative for symptom management (18/99, 18%), providing psychological support (14/99, 14%), improving cognitive function (12/99, 12%), and improving medication adherence (7/99, 7%). A total of 39 studies mentioned the gamification effect; however, we did not find a unified evaluation standard.


CONCLUSIONS
This scoping review focuses on gamification designs for chronic disease self-management and summarizes the realization forms and functions of gamification in self-management for different patient populations. With practice in a gamified internet-based environment, patients can not only master the knowledge and skills of self-management in fascinating scenarios but also benefit from gaming experience and make better health-related decisions in real life. It is worth noting that a comprehensive evaluation of the users as well as a personalized and targeted intervention should be developed before gamification.

The Use of Gamification in Self-management of Patients with Chronic Diseases: A Scoping Review (Preprint)

The use of virtual reality (VR) for stroke rehabilitation has been implemented during the last decade. At present, most studies still focus on the effects of VR on upper limb rehabilitation, and few studies have explored VR games, VR system designs, and rehabilitation modes for upper limb rehabilitation. This study aims to (1) evaluate the rehabilitation effect of stroke patients using a game-based VR upper limb rehabilitation system in clinical settings; (2) investigate the impact of custom and commercial VR games on patients in clinical settings; and (3) review VR upper limb rehabilitation modes. The PubMed, ScienceDirect, Scopus, Web of Science, and IEEE Xplore databases were searched, and related literature published through December 2021 was included. A total of 4700 articles were retrieved according to the search strategy. We identified 24 studies, including 793 patients. We conducted a systematic search for randomized controlled trials with adult stroke patients to analyze the effect of game-based VR upper limb rehabilitation systems. A meta-analysis was conducted to compare the effects of upper limb function, hand dexterity, daily living ability, and cognitive function between the experimental group (EG, using VR for upper limb rehabilitation) and control group (CG, receiving conventional rehabilitation, including physical therapy and occupational therapy). We also conducted an analysis of both custom and commercial games. The results of the meta-analysis proved that game-based VR upper limb rehabilitation therapy for cerebral apoplexy is an effective method of rehabilitation in clinical settings and is more effective than traditional rehabilitation in improving patients' upper limb function and hand mobility. Custom games heal better than commercial games. This study only includes nonimmersive device rehabilitation modes due to research constraints and classified them into four categories. The mode of VR games combined with rehabilitation instruments may solve the problem that patients with severe upper limb dysfunction cannot operate games. Whether the use of immersive VR devices and the fun of games will affect patients' rehabilitation motivation and effect is the direction of future research.

Game-Based Virtual Reality System for Upper Limb Rehabilitation After Stroke in a Clinical Environment: Systematic Review and Meta-Analysis.

Metaverse is posed to change the world and revolutionalize the way we work, play, and socialize with one another. In recent years, both capital circles and large technology companies have started to pay attention to this emerging field, setting off a wave of metaverse upsurge. The academic world can and should also contribute to the development and evolution of metaverse. In this paper, we put forward a technology framework of metaverse from a macro perspective to discuss technical support for realizing the vision of large-scale and massive human-computer interaction in metaverse. We trace the latest technology and related applications that enable the development of metaverse. We also compare them with the proposed technical framework to determine the current gaps, which point out the direction for further research in the future. 

Metaverse and Human-Computer Interaction: A Technology Framework for 3D Virtual Worlds

BACKGROUND
Robot-assisted upper-limb rehabilitation has been studied for many years, with many randomised controlled trials (RCTs) investigating the effects of robotic-assisted training on affected limbs. The current trend directs towards end-effector devices. However, most studies have focused on the effectiveness of rehabilitation devices, but studies on device sizes are relatively few.


GOAL
Systematically review the effect of a portable rehabilitation robot (PRR) on the rehabilitation effectiveness of paralysed upper limbs compared with non-robotic therapy.


METHODS
A meta-analysis was conducted on literature that included the Fugl-Meyer Assessment (FMA) obtained from the PubMed and Web of Science (WoS) electronic databases until June 2023.


RESULTS
A total of 9 studies, which included RCTs, were completed and a meta-analysis was conducted on 8 of them. The analysis involved 295 patients. The influence on upper-limb function before and after treatment in a clinical environment is analysed by comparing the experimental group using the portable upper-limb rehabilitation robot with the control group using conventional therapy. The result shows that portable robots prove to be effective (FMA: SMD = 0.696, 95% = 0.099 to.293, p < 0.05).


DISCUSSION
Both robot-assisted and conventional rehabilitation effects are comparable. In some studies, PRR performs better than conventional rehabilitation, but conventional treatments are still irreplaceable. Smaller size with better portability has its advantages, and portable upper-limb rehabilitation robots are feasible in clinical rehabilitation.


CONCLUSION
Although portable upper-limb rehabilitation robots are clinically beneficial, few studies have focused on portability. Further research should focus on modular design so that rehabilitation robots can be decomposed, which benefits remote rehabilitation and household applications.

Portable robots for upper-limb rehabilitation after stroke: a systematic review and meta-analysis.

In the post-epidemic era, health has become people’s major concern. An increasing number of people have shown their interest in the planning and construction of healthy cities, which are related to the quality of life and the choice of the city to live in. The concept of a healthy city has received extensive attention since it was first proposed in the 1980s. To construct healthy cities is conducive to addressing health-related problems in the city, while also driving sustainable development for the city in the long run. With the continuous practice and development of healthy cities in recent years, healthy cities have been more closely linked to all aspects of urban development on the premise that the aim of healthy city construction is to improve the health of the residents and promote sustainable development. Based on the literature and case studies of Seoul, this study discusses the beneficial experience of building a healthy city from the perspective of brand construction, and puts forward the connotation of multi-disciplinary cooperative healthy city brand construction. 

Research on Healthy City Construction from the Perspective of City Brand: Focus on Case of Seoul

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Game-Based Virtual Reality System for Upper Limb Rehabilitation After Stroke in a Clinical Environment: Systematic Review and Meta-Analysis.

Metaverse and Human-Computer Interaction: A Technology Framework for 3D Virtual Worlds

Portable robots for upper-limb rehabilitation after stroke: a systematic review and meta-analysis.

Research on Healthy City Construction from the Perspective of City Brand: Focus on Case of Seoul